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Products:Neuroscience >> Neurotransmission >> Receptors / Channels >> Potassium Channels
Overview
Product name
Anti-KCNS3 antibody
See all KCNS3 products (2) ...
Description
Chicken polyclonal to KCNS3
Specificity
ab26164 recognises potassium voltage-gated channel delayed-rectifier protein S3.
Tested applications
WB, ICCmore details
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
Synthetic peptide, corresponding to amino acids 26-224 of Human KCNS3
Positive control
293 cell extract, Hela cell extract
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgY
Research areas
Neuroscience >> Neurotransmission >> Receptors / Channels >> Potassium Channels
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Western blot - KCNS3 antibody (ab26164)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab26164 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/500Detects a band of approximately 56 kDa (predicted molecular weight: 56 kDa).
ICC
ICC: 1/200ICC: 1/200
Target
Function
Potassium channel subunit. Modulates channel activity and reduces the ion flow.
Tissue specificity
Detected in most tissues, but not in peripheral blood lymphocytes. The highest levels of expression are in lung.
Sequence similarities
Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily.
Domain
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Cellular localization
Cell membrane. May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.
Target information above from: UniProt accessionQ9BQ31
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Delayed rectifier K(+) channel alpha subunit 3 antibody
- Delayed rectifier K+ channel alpha subunit 3 antibody
- Delayed-rectifier K(+) channel alpha subunit 3 antibody
see all
Database links
- Entrez Gene: 3790 Human
- Entrez Gene: 238076 Mouse
- Entrez Gene: 83588 Rat
- Omim: 603888 Human
- SwissProt: Q4ZFY1 Human
- SwissProt: Q9BQ31 Human
- SwissProt: Q8BQZ8 Mouse
- SwissProt: O88759 Rat
see all
Anti-KCNS3 antibody images:
Western blot - KCNS3 antibody (ab26164)
Predicted band size : 56 kDa
Observed band size : 56,75 kDa (why is the actual band size different from the predicted?)
Additional bands at : 25 kDa. We are unsure as to the identity of these extra bands.
E coli-derived fusion protein (1), 293 cell extract (2), and Hela cell extract (3) as test antigen. Affinity-purified IgY dilution: 1:2000 (or 1:500 for cell extract), Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development.
References for Anti-KCNS3 antibody (ab26164)
This product has been referenced in:
- Chen Met al. Voltage-gated K(+) channels sensitive to stromatoxin-1 regulate myogenic and neurogenic contractions of rat urinary bladder smooth muscle. Am J Physiol Regul Integr Comp Physiol 299:R177-84 (2010). WB; Rat.Read more (PubMed: 20393158) »
- Bocksteins Eet al. Kv2.1 and silent Kv subunits underlie the delayed rectifier K+ current in cultured small mouse DRG neurons. Am J Physiol Cell Physiol 296:C1271-8 (2009).Read more (PubMed: 19357235) »
See all 2 publications for this product
Publishing research using ab26164? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"