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This fast track antibody is not yet fully characterised. It is subject to these terms and conditions
Overview
Product name
Anti-KDM4C / GASC1 / JMJD2C antibody
See all KDM4C / GASC1 / JMJD2C products (5) ...
Description
Rabbit polyclonal to KDM4C / GASC1 / JMJD2C
This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »
Cross reactivity
Predicted to work with
Saccharomyces cerevisiae
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 600 - 700 of Saccharomyces cerevisiae RPH1.
(Peptide available as ab41577.)
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 1% BSA, PBS, pH 7.4
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Applications
Application notes
This antibody gave a positive result in ELISA against the immunizing peptide (ab41577).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Tissue specificity
Overexpressed in several esophageal squamous cell carcinomas (ESCs).
Sequence similarities
Belongs to the JHDM3 histone demethylase family.
Contains 1 JmjC domain.
Contains 1 JmjN domain.
Contains 2 PHD-type zinc fingers.
Contains 2 Tudor domains.
Domain
The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails.
Cellular localization
Nucleus.
Target information above from: UniProt accessionQ9H3R0
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- JmjC domain-containing histone demethylation protein 3C antibody
- Jumonji domain-containing protein 2C antibody
- bA146B14.1 antibody
see all
References for Anti-KDM4C / GASC1 / JMJD2C antibody (ab40173)
ab40173 has not yet been referenced specifically in any publications.
Publishing research using ab40173? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"