KDM5C / Jarid1C / SMCX antibody (ab34718)

Product Name 

KDM5C / Jarid1C / SMCX antibody

Product type 

Primary antibodies

Description 

Rabbit polyclonal to KDM5C / Jarid1C / SMCX

Immunogen 

Synthetic peptide conjugated to KLH derived from within residues 1500 to the C-terminus of Human Jarid1C / SMCX.

(Peptide available as ab35501.)

Reacts with 

Hu

Predicted to react 
(species key)

Pig
(Due to sequence homology)

Tested applications 
(see key)

WB

Abreviews 

Customer reviews (see key)

Read about Abreviews (Read all Abreviews)

Application notes 
(see key)

Recommended dilutions
WB: 1/250. Detects a band of approximately 176 kDa (predicted molecular weight: 176 kDa).


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

HEK 293 (Human embryonic kidney cell line) Whole Cell Lysate.

Cellular localization 

Nuclear

Research areas 

Chromatin and Nuclear Signaling >> Chromatin Modifying Enzymes >> Jumonji containing proteins
Chromatin and Nuclear Signaling >> Transcription >> Co-factors
Chromatin and Nuclear Signaling >> Transcription >> Other factors
Chromatin and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Co-activators/co-repressors

Relevance 

KDM5C / JARID1C / SMCX is expressed in a variety of tissues and it's highest levels are found in skeletal and brain extracts. Defects in SMCX are the cause of X-linked mental retardation (XLMR). Etiologically, mental retardation is a very heterogeneous condition that involves environmental, stochastic and/or genetic factors.

KDM5C specifically demethylates di and tri methyl histone H3 at K4.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

Preservative: 0.02% Sodium Azide
Constituents: 1% BSA, PBS, pH 7.4

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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