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Anti-KLF6 antibody (ab45302)

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Overview

Product name

Anti-KLF6 antibody
See all KLF6 products (3) ...

Description

Rabbit polyclonal to KLF6

Tested applications

WBmore details

Cross reactivity

Reacts with

Human

Immunogen

Recombinant Human KLF6 protein fragment with an N-terminal fusion tag.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

Research areas

Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> Krueppel like factor
Epigenetics and Nuclear Signaling >> Transcription >> Krueppel like factor
Stem Cells >> Hematopoietic Progenitors >> Intracellular Molecules
Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> Developmental Families >> Other
Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> Zinc Finger

  • Western blot - KLF6 antibody (ab45302)Western blot - KLF6 antibody (ab45302) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab45302 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application notes

WB: Use at an assay dependent dilution. Predicted molecular weight: 31 kDa.

This antibody was tested using a recombinant KLF6 protein fragment (immunogen) only. We have no data on detection of endogenous protein.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development.

Tissue specificity

Highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and colon. Weakly expressed in pancreas, lung, liver, heart and skeletal muscle. Also expressed in fetal brain, spleen and thymus.

Involvement in disease

Defects in KLF6 are a cause of gastric cancer (GASC) [MIM:613659]; also called gastric cancer intestinal or stomach cancer. Gastric cancer is a malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
Defects in KLF6 are a cause of prostate cancer (PC) [MIM:176807]. Prostate cancer is a malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 3 C2H2-type zinc fingers.

Domain

The acidic N-terminal part may favor interaction with the basic domain of transcription factors.

Cellular localization

Nucleus.

Target information above from: UniProt accessionQ99612 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • B cell derived protein 1 antibody
  • B-cell-derived protein 1 antibody
  • BCD1 antibody
  • COPEB antibody
  • Core promoter element-binding protein antibody
  • CPBP antibody
  • GC rich sites binding factor GBF antibody
  • GC-rich sites-binding factor GBF antibody
  • Klf6 antibody
  • KLF6_HUMAN antibody
  • Krueppel-like factor 6 antibody
  • Proto-oncogene BCD1 antibody
  • Suppressor of tumorigenicity 12 protein antibody
  • Transcription factor Zf9 antibody
  • Zf9 antibody
see all

Database links

Anti-KLF6 antibody images:

  Western blot - KLF6 antibody (ab45302)

Western blot - KLF6 antibody (ab45302)

All lanes : Anti-KLF6 antibody (ab45302) at 1/1000 dilution

Lane 1 : Recombinant KLF6 protein (15µg)
Lane 2 : Negative control protein (15µg)


Predicted band size : 31 kDa


Western blot developed using a DAB staining kit.

References for Anti-KLF6 antibody (ab45302)

ab45302 has not yet been referenced specifically in any publications.

Publishing research using ab45302? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"