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- Secondary antibodies
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Product name
Anti-KLRG1 antibody [2F1] (FITC)
See all KLRG1 products (5) ...
Description
Syrian Hamster monoclonal [2F1] to KLRG1 (FITC)
Conjugation
FITC
Specificity
This antibody is specific for KLRG1, MW 30-38kDa.
Tested applications
Flow Cyt, IPmore details
Cross reactivity
Reacts with
Mouse
Immunogen
Activated NK (A-LAK) cells from B6 (H-2b)mice.
Properties
Form
Liquid
Storage instructions
Store at +4°C in the dark.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Monoclonal
Clone number
2F1
Isotype
IgG
Research areas
Applications
Show applications key
Our Abpromise guarantee covers the use of ab24867 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Flow Cyt: Use 1µg for 106 cells.
IP: Use at an assay dependent dilution.
Target
Relevance
Killer cell lectin-like receptor G1 (KLRG1; formerly known as mouse MAFA or 2F1 Ag), a homodimeric member of the lectin-like type 2 transmembrane receptor family that contain characteristic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domains. These ITIMs interact with the SH2 domains of protein phosphatases such as SHP1. Cell surface expression of KLRG1 is up-regulated by expression of MHC class I molecules. The effect of MHC class I expression is indirect, and can be mediated by interactions with class I-specific Ly49 inhibitory receptors.
Cellular localization
Membrane; Single-pass type II membrane protein
Alternative names
- 2F1 Ag antibody
- 2F1 antibody
- 2F1-Ag antibody
see all
Database links
- Entrez Gene: 50928 Mouse
- GenBank: NM_016970 Mouse
- SwissProt: O88713 Mouse
- Unigene: 20434 Mouse
References for Anti-KLRG1 antibody [2F1] (FITC) (ab24867)
This product has been referenced in:
- Valkenburg SA et al. Early priming minimizes the age-related immune compromise of CD8? T cell diversity and function. PLoS Pathog 8:e1002544 (2012). Flow Cyt; Mouse.Read more (PubMed: 22383879) »
- Durward M et al. Active Evasion of CTL Mediated Killing and Low Quality Responding CD8+ T Cells Contribute to Persistence of Brucellosis. PLoS One 7:e34925 (2012). Flow Cyt; Mouse.Read more (PubMed: 22558103) »
See all 4 publications for this product
Publishing research using ab24867? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"