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Anti-KLRG1 antibody [2F1] (Phycoerythrin) (ab25205)

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Overview

Product name

Anti-KLRG1 antibody [2F1] (Phycoerythrin)
See all KLRG1 products (5) ...

Description

Syrian Hamster monoclonal [2F1] to KLRG1 (Phycoerythrin)

Conjugation

Phycoerythrin

Specificity

The monoclonal antibody 2F1 reacts with mouse killer cell lectin-like receptor G1 (KLRG1; formerly known as mouse MAFA or 2F1 Ag). This antibody stains 30-60% of NK1.1+ CD3- splenocytes, and a small fraction of T cells in all mouse strains tested (C57BL/6, BALB/c, 129/J, C3H.SW, AKR/J, SJL).

Tested applications

Flow Cyt, IPmore details

Cross reactivity

Reacts with

Mouse

Immunogen

Tissue / cell preparation (Mouse) - Activated NK (A-LAK) cells from B6 (H-2b) mice.

Properties

Form

Liquid

Storage instructions

Store at +4°C in the dark. Do not freeze.

Storage buffer

Preservative: 0.09% Sodium Azide
Constituents: 16% Sucrose, PBS; Stabilizing agent

Concentration

Concentration information loading...

Clonality

Monoclonal

Clone number

2F1

Isotype

IgG

Research areas

Immunology >> Immunoglobulins >> Receptors

Applications

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Our Abpromise guarantee covers the use of ab25205 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

Killer cell lectin-like receptor G1 (KLRG1; formerly known as mouse MAFA or 2F1 Ag), a homodimeric member of the lectin-like type 2 transmembrane receptor family that contain characteristic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domains. These ITIMs interact with the SH2 domains of protein phosphatases such as SHP1. Cell surface expression of KLRG1 is up-regulated by expression of MHC class I molecules. The effect of MHC class I expression is indirect, and can be mediated by interactions with class I-specific Ly49 inhibitory receptors.

Cellular localization

Membrane; Single-pass type II membrane protein

Alternative names

  • 2F1 Ag antibody
  • 2F1 antibody
  • 2F1-Ag antibody
  • C type lectin domain family 15 member A antibody
  • CLEC15A antibody
  • ITIM containing receptor MAFA L antibody
  • Killer cell lectin like receptor G1 antibody
  • Killer cell lectin like receptor subfamily G member 1 antibody
  • KLRG 1 antibody
  • KLRG1 protein antibody
  • MAFA 2F1 antibody
  • MAFA antibody
  • MAFA L antibody
  • MAFA like antibody
  • MAFA like receptor antibody
  • MAFAL antibody
  • Mast cell function associated antigen (ITIM containing) antibody
  • Mast cell function associated antigen antibody
  • Mast cell function-associated antigen 2F1 antibody
  • Mast cell function-associated antigen, rat, homolog of antibody
  • MGC13600 antibody
see all

Database links

References for Anti-KLRG1 antibody [2F1] (Phycoerythrin) (ab25205)

This product has been referenced in:

  • Allie SR  et al. Programmed death 1 regulates development of central memory CD8 T cells after acute viral infection. J Immunol 186:6280-6 (2011). Flow Cyt; Mouse.Read more (PubMed: 21525385) »
  • Blackburn SD  et al. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol 10:29-37 (2009). Flow Cyt; Mouse.Read more (PubMed: 19043418) »

See all 2 publications for this product

Publishing research using ab25205? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"