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Product name
KN-62
Description
CaM kinase II inhibitor. P2X7 antagonist.
Biological description
Cell-permeable, reversible and selective inhibitor of CaM kinase II (IC50 = 500 nM). Interacts with the calmodulin binding site of the enzyme. At higher concentrations reported to inhibit GSK3β, PRAK and MAPKAP-K2. Also potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).
Purity
> 98%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
4-[(2S)-2-[(5-Isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl] phenylisoquinolinesulfonic acid ester
Molecular Weight
721.84
Chemical structure
Molecular formula
C38H35N5O6S2
CAS Number
127191-97-3
Solubility
Soluble in DMSO to 100 mM
Storage instructions
Store at -20°C (desiccating conditions).
Research areas
Biochemicals >> Pharmacology >> Receptors & Transporters >> Purinergics >> P2 >> P2X >> Antagonists
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> CAM Kinase
Biochemicals >> Chemical Type >> Biochemicals
References for KN-62 (ab120421)
This product has been referenced in:
- Davies SP et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351:95-105 (2000).Read more (PubMed: 10998351) »
- Chessell IP et al. Effects of antagonists at the human recombinant P2X7 receptor. Br J Pharmacol 124:1314-20 (1998).Read more (PubMed: 9720806) »
See all 4 publications for this product
Publishing research using ab120421? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"