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Overview

  • Product nameAnti-KREMEN2 antibodySee all KREMEN2 primary antibodies ...
  • Description
    Mouse polyclonal to KREMEN2
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length human KREMEN2 protein (NP_078783)

  • Positive controlKREMEN2 transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab68906 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: 1/500 - 1/1000. Detects a band of approximately 49 kDa (predicted molecular weight: 49 kDa).

Target

  • FunctionReceptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane.
  • Sequence similaritiesContains 1 CUB domain.
    Contains 1 kringle domain.
    Contains 1 WSC domain.
  • DomainBinding to ERLEC1 is mediated by the oligosaccharides linked to the kringle domain.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession Q8NCW0 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        Dickkopf receptor 2 antibodyKREM2_HUMAN antibodyKREMEN 2 antibody
        Kremen protein 2 antibodyKremen protein 2 precursor antibodyKremen2 antibodyKringle containing protein marking the eye and the nose antibodyKringle containing transmembrane protein 2 antibodyKringle domain containing transmembrane protein 2 antibodyKringle domain-containing transmembrane protein 2 antibodyKringle-containing protein marking the eye and the nose antibodyKRM 2 antibodyKRM2 antibodyMGC10791 antibodyMGC16709 antibody
      see all

    Anti-KREMEN2 antibody images

    • Western blot - KREMEN2 antibody (ab68906)
      Western blot - KREMEN2 antibody (ab68906)
      All lanes : Anti-KREMEN2 antibody (ab68906) at 1/500 dilution

      Lane 1 : KREMEN2 transfected 293T cell lysate
      Lane 2 : Non-transfected 293T cell lysate

      Lysates/proteins at 25 µg per lane.

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

      Predicted band size : 49 kDa
      Observed band size : 49 kDa

    References for Anti-KREMEN2 antibody (ab68906)

    This product has been referenced in:
    • Kapinas K  et al. miR-29 Modulates Wnt Signaling in Human Osteoblasts through a Positive Feedback Loop. J Biol Chem 285:25221-31 (2010). WB ; Human . Read more (PubMed: 20551325) »

    See 1 Publication for this product

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    Western blot abreview for Anti-KREMEN2 antibody

     Excellent
    Abreviews
    Application Western blot
    Sample Human Cell lysate - whole cell (mesenchymal cell)
    Loading amount 30 µg
    Specification mesenchymal cell
    Gel Running Conditions Reduced Denaturing
    Blocking step Milk as blocking agent for 20 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 4°C
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    Verified customer

    Submitted Nov 09 2009

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"