Overview

  • Product nameAnti-KREMEN2 antibody
    See all KREMEN2 primary antibodies
  • Description
    Mouse polyclonal to KREMEN2
  • Tested applicationsWBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length human KREMEN2 protein (NP_078783)

  • Positive control
    • KREMEN2 transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab68906 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 49 kDa (predicted molecular weight: 49 kDa).

Target

  • FunctionReceptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane.
  • Sequence similaritiesContains 1 CUB domain.
    Contains 1 kringle domain.
    Contains 1 WSC domain.
  • DomainBinding to ERLEC1 is mediated by the oligosaccharides linked to the kringle domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Dickkopf receptor 2 antibody
    • KREM2_HUMAN antibody
    • KREMEN 2 antibody
    • Kremen protein 2 antibody
    • Kremen protein 2 precursor antibody
    • Kremen2 antibody
    • Kringle containing protein marking the eye and the nose antibody
    • Kringle containing transmembrane protein 2 antibody
    • Kringle domain containing transmembrane protein 2 antibody
    • Kringle domain-containing transmembrane protein 2 antibody
    • Kringle-containing protein marking the eye and the nose antibody
    • KRM 2 antibody
    • KRM2 antibody
    • MGC10791 antibody
    • MGC16709 antibody
    see all

Anti-KREMEN2 antibody images

  • All lanes : Anti-KREMEN2 antibody (ab68906) at 1/500 dilution

    Lane 1 : KREMEN2 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 49 kDa
    Observed band size : 49 kDa

References for Anti-KREMEN2 antibody (ab68906)

This product has been referenced in:
  • Kapinas K  et al. miR-29 Modulates Wnt Signaling in Human Osteoblasts through a Positive Feedback Loop. J Biol Chem 285:25221-31 (2010). WB ; Human . Read more (PubMed: 20551325) »

See 1 Publication for this product

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Human Cell lysate - whole cell (mesenchymal cell)
Loading amount 30 µg
Specification mesenchymal cell
Gel Running Conditions Reduced Denaturing
Blocking step Milk as blocking agent for 20 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 4°C
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Submitted Nov 09 2009

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"