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Products:Cardiovascular >> Blood >> Serum Proteins
Overview
Product name
Anti-Kallikrein 1 antibody
See all Kallikrein 1 products (5) ...
Description
Rabbit polyclonal to Kallikrein 1
Specificity
Monospecific for tissue kallikrein. Crossreacts with tissue kallikreins from urine, pancreas, saliva, kidney, intestine, seminal plasma and serum. Does not crossreact with plasma kallikrein.
Tested applications
ELISAmore details
Cross reactivity
Reacts with
Human
Immunogen
Full length native kallikrein from tissue (Human)
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: 40% Glycerol, PBS, pH 7.2
Concentration
Concentration information loading...
Purification notes
Purified by ammonium sulfate fractionation.
Clonality
Polyclonal
Isotype
IgG
Research areas
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Serine protease >> Kallikreins
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> Kallikreins
Cancer >> Invasion/microenvironment >> Angiogenesis >> ECM enzymes >> Kallikreins
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> Kallikreins
Cardiovascular >> Blood >> Coagulation >> Intrinsic
Cardiovascular >> Blood >> Serum Proteins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab31507 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA
ELISA: 1/500 - 1/3000.ELISA: 1/500 - 1/3000.
Target
Function
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
Tissue specificity
Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84.
Sequence similarities
Belongs to the peptidase S1 family. Kallikrein subfamily.
Contains 1 peptidase S1 domain.
Post-translational
modifications
The O-linked polysaccharides on Ser-93, Ser-104 and Ser-167 are probably the mucin type linked to GalNAc. In PubMed:3163150, GalNAc was detected with the corresponding peptides but not located.
Target information above from: UniProt accessionP06870
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- hK1 antibody
- Kidney/pancreas/salivary gland kallikrein antibody
- Glandular kallikrein 1 antibody
see all
Database links
- Entrez Gene: 3816 Human
- Omim: 147910 Human
- SwissProt: P06870 Human
- Unigene: 123107 Human
References for Anti-Kallikrein 1 antibody (ab31507)
This product has been referenced in:
- Tang SCet al. Bradykinin and high glucose promote renal tubular inflammation. Nephrol Dial Transplant : (2009).Read more (PubMed: 19923143) »
See 1 publication for this product
Publishing research using ab31507? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"