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Product Name
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Kallikrein 1 antibody
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See all Kallikrein 1 antibodies (5)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to Kallikrein 1
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Immunogen
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Full length native kallikrein from tissue (Human)
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Reacts with
(species key)
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Hu
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Specificity
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Monospecific for tissue kallikrein. Crossreacts with tissue kallikreins from urine, pancreas, saliva, kidney, intestine, seminal plasma and serum. Does not crossreact with plasma kallikrein.
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Tested applications
(see key)
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ELISA
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ELISA: 1/500 - 1/3000.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cytoplasmic
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Research areas
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Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Serine protease >> Kallikreins
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> Kallikreins
Cancer >> Invasion/microenvironment >> Angiogenesis >> ECM enzymes >> Kallikreins
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> Kallikreins
Cardiovascular >> Blood >> Coagulation >> Intrinsic
Cardiovascular >> Blood >> Serum Proteins
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Relevance
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Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. Kallikrein 1 releases the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. Low renal synthesis and urinary excretion of tissue kallikrein have been linked to hypertension in animals and humans and the kallikrein-kinin system may be involved in the development or progression of cardiovascular disease.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Storage buffer
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Preservative: 0.1% Sodium Azide
Constituents: 40% Glycerol, PBS, pH 7.2 Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Sodium Azide MSDS
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Purification notes
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Purified by ammonium sulfate fractionation.
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Form
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Liquid
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Concentration
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Batch dependent within range: 1.65 - 1.65 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Kallikrein 1 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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References for Kallikrein 1 antibody (ab31507)
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This product has been used in:
Tang SC et al. Bradykinin and high glucose promote renal tubular inflammation. Nephrol Dial Transplant : (2009). PubMed: 19923143
If you publish research using ab31507 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to Kallikrein 1
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Kallikrein 1 antibody - more information
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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