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Kallikrein 1 peptide (Kallikrein loop) (ab41419)

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Overview

Product name

Kallikrein 1 peptide (Kallikrein loop)
See all Kallikrein 1 products (4) ...

Protein description

This peptide was used as an immunogen for ab28289 - Kallikrein 1 antibody - Kallikrein loop.

Properties

Purity

>95% by SDS-PAGE

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75

Concentration

Concentration information loading...

Research areas

Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Serine protease >> Kallikreins
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> Kallikreins
Cancer >> Invasion/microenvironment >> Angiogenesis >> ECM enzymes >> Kallikreins
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> Kallikreins
Cardiovascular >> Blood >> Coagulation >> Intrinsic
Cardiovascular >> Blood >> Serum Proteins

Applications

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Our Abpromise guarantee covers the use of ab41419 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ELISA

     

  • WB

     

Application notes

ELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. This peptide can be used with studies using ab28289. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Protein info

Function

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Tissue specificity

Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84.

Sequence similarities

Belongs to the peptidase S1 family. Kallikrein subfamily.
Contains 1 peptidase S1 domain.

Post-translational
modifications

The O-linked polysaccharides on Ser-93, Ser-104 and Ser-167 are probably the mucin type linked to GalNAc. In PubMed:3163150, GalNAc was detected with the corresponding peptides but not located.

Target information above from: UniProt accessionP06870 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

References for Kallikrein 1 peptide (Kallikrein loop) (ab41419)

This product has been referenced in:

See 1 publication for this product

Publishing research using ab41419? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"