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Product Name
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Kallikrein 2 antibody [6B7]
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See all Kallikrein 2 antibodies (4)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [6B7] to Kallikrein 2
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Immunogen
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Tissue / cell preparation (Human) - Line tumor cells expressing human Kallikrein 2.
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Reacts with
(species key)
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Hu
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Specificity
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This antibody reacts with human Kallikrein 2. This is no detectable reactivity with PSA.
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Tested applications
(see key)
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AP, ELISA, ICC, IHC-P
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Abreviews
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Application notes
(see key)
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Recommended dilutions
AP: Use at an assay dependent dilution.
ELISA: Use at an assay dependent dilution.
ICC: Use at an assay dependent dilution.
IHC-P: Use at an assay dependent dilution. As a guideline use at 18ug/ml for sections. Perform heat mediated antigen retrieval via the microwave method before commencing with IHC staining protocol.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Research areas
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Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Serine protease >> Kallikreins
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> Kallikreins
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> Kallikreins
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Relevance
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Kallikreins (KLKs) are a subgroup of trypsin-like serine proteases and are implicated in carcinogenesis. Kallikrein 2 is most closely related to Kallikrein 3 (PSA), with 78% identity and with kallikrein 1, at 68% identity. Like Kallikrein 3, Kallikrein 2 is found in greatest abundance in the prostate, but at much lower levels than Kallikrein 3. In addition, Kallikrein 2 seems to be more labile than Kallikrein 1 or Kallikrein 3 and is often found in a cleaved form. Kallikrein 2 is inhibited by Protein C Inhibitor (PCI).
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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6B7
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Isotype
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IgG1
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Purity
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Protein G purified
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Storage buffer
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Preservative: 0.1% Sodium Azide
Constituents: PBS Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Kallikrein 2 antibody [6B7] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to Kallikrein 2
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Kallikrein 2 antibody [6B7] - more information
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