Anti-Kallikrein 4 antibody - Catalytic domain (ab40950)

Overview

• Product nameAnti-Kallikrein 4 antibody - Catalytic domainSee all Kallikrein 4 primary antibodies ...
• Description
  Rabbit polyclonal to Kallikrein 4 - Catalytic domain
• SpecificityThis antibody is specific for Kallikrein 4, it does not react with the other Kallikreins (1-3, 5-15).
• Tested applicationsSDS-PAGE, WB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide based on the catalytic domain of human Kallikrein 4. (Peptide available as ab43086.)

• General notesDifferent splice variants of Kallikrein 4 encode for proteins of 195, 159 and 75 amino acids, with predicted masses of 20.6, 16.9 and 8 kDa respectively, although expression of the related proteins is unknown.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.05% Sodium Azide
  Constituents: 50% Glycerol
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Cancer
  • Invasion/microenvironment
  • ECM
  • Extracellular matrix
  • Kallikreins

  • Signal Transduction
  • Cytoskeleton / ECM
  • Extracellular Matrix
  • ECM Enzymes
  • Kallikreins

  • Cell Biology
  • Proteolysis / Ubiquitin
  • Proteolytic enzymes
  • Serine protease
  • Kallikreins

Applications

Target

• Tissue specificityExpressed in prostate.
• Involvement in diseaseDefects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:204700]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.
• Sequence similaritiesBelongs to the peptidase S1 family. Kallikrein subfamily.
  Contains 1 peptidase S1 domain.
• Cellular localizationSecreted.

Target information above from: UniProt accession Q9Y5K2 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 9622 Human
  • Entrez Gene: 9622 Human
  • Omim: 603767 Human
  • SwissProt: Q9Y5K2 Human
  • SwissProt: Q9Y5K2 Human
  • Unigene: 218366 Human

• Alternative names
  7S nerve growth factor alpha chain antibodyAI2A1 antibodyAlpha-NGF antibody

  Androgen-regulated message 1 antibodyARM1 antibodyEC 3.4.21.- antibodyEMSP 1 antibodyEMSP antibodyEMSP1 antibodyEnamel Matrix Serine Protease 1 antibodyEnamel matrix serine proteinase 1 antibodyHK4 antibodyKallikrein 1-related peptidase-like b4 antibodyKallikrein 4 (prostase, enamel matrix, prostate) antibodyKallikrein 4 antibodyKallikrein antibodyKallikrein L1 antibodyKallikrein like protein 1 antibodyKallikrein like protein 1 antibodyKallikrein related-peptidase 4 (prostase, enamel matrix, prostate) antibodyKallikrein-4 antibodyKallikrein-like protein 1 antibodyKallikrein-related peptidase 4 antibodyKLK 4 antibodyKLK L1 antibodyKLK-L1 antibodyKLK4 antibodyKLK4 antibodyKLK4_HUMAN antibodyMGC116827 antibodyMGC116828 antibodyProstase antibodyProtease Serine 17 antibodyPRSS 17 antibodyPRSS17 antibodyPSTS antibodySerine protease 17 antibody

  see all

Anti-Kallikrein 4 antibody - Catalytic domain images

• 

  Western blot - Kallikrein 4 antibody - Catalytic domain (ab40950)
  All lanes : Anti-Kallikrein 4 antibody - Catalytic domain (ab40950) at 1/1000 dilution
  
  Lane 1 : Kallikrein 4 at 0.05 µg
  Lane 2 : Kallikrein 4 at 0.01 µg
  Lane 3 : Kallikrein 4 at 0.001 µg
  
  
  Predicted band size : 27 kDa
  Observed band size : 30 kDa (why is the actual band size different from the predicted?)
  Additional bands at : 50 kDa (possible post-translational modification).

Protocols

• Recommended WB protocol