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Products:Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> Kallikreins
Overview
Product name
Anti-Kallikrein 4 antibody
See all Kallikrein 4 products (5) ...
Description
Rabbit polyclonal to Kallikrein 4
Specificity
Reacts with residues 242-254 [KFTEWIEKTVQAS] of the human 39 kDa LKL-L1 protein.
Tested applications
Cross reactivity
Reacts with
Human
Positive control
Synthetic peptide corresponding to residues 242 - 254 [KFTEWIEKTVQAS] of the human LKL L1 protein.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
PBS with 0.02% sodium azide
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Polyclonal
Isotype
IgG
Research areas
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Serine protease >> Kallikreins
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> Kallikreins
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> Kallikreins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab3636 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
Application notes
WB: 1/500 - 1/1000.
In Western blot, this antibody is expected to detect a band of approximately 39 kDa, which corresponds to the predicted molecular weight of KLK L1.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Tissue specificity
Expressed in prostate.
Involvement in disease
Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:204700]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.
Sequence similarities
Belongs to the peptidase S1 family. Kallikrein subfamily.
Contains 1 peptidase S1 domain.
Cellular localization
Secreted.
Target information above from: UniProt accessionQ9Y5K2
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- EC 3.4.21.- antibody
- 7S nerve growth factor alpha chain antibody
- AI2A1 antibody
see all
Database links
- Entrez Gene: 9622 Human
- Omim: 603767 Human
- SwissProt: Q9Y5K2 Human
- Unigene: 218366 Human
References for Anti-Kallikrein 4 antibody (ab3636)
This product has been referenced in:
- Stephenson SAet al. Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4. J Biol Chem 274:23210-4 (1999).Read more (PubMed: 10438493) »
See 1 publication for this product
Publishing research using ab3636? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"