|
|
|
|
|
Product Name
|
Kappa light chain antibody [4G7]
|
| |
See all Kappa light chain antibodies (31)...
|
|
Product type
|
Primary antibodies
|
|
Description
|
Mouse monoclonal [4G7] to Kappa light chain
|
|
Immunogen
|
Mixture of light chains of human immunoglobulin.
|
|
Reacts with
(species key)
|
Hu
|
|
Specificity
|
Specific for independent constantly expressed epitope of kappa chain. Reacts with free and heavy chain-associated kappa chains.
|
|
Tested applications
(see key)
|
ELISA, IHC-Fr, IHC-P
|
|
|
Abreviews
|
|
|
|
Application notes
(see key)
|
Recommended dilutions
ELISA: Use at an assay dependent dilution. Specific antibody titer is 1/100000 by indirect ELISA
IHC-P: Use at an assay dependent dilution.
IHC-Fr: Use at an assay dependent dilution.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
|
|
Cellular localization
|
Cytoplasmic
|
|
Research areas
|
Immunology >> Immunoglobulins >> Light Chain >> Kappa
|
|
Relevance
|
Immunoglobulins belong to a group of related glyco proteins which make up 20% of serum proteins. Antigens and immunoglobulins react to confer immunity to individuals. Immunoglobulins have similar structures of two identical heavy chains and two identical light chains. Both the heavy chains and the light chains are divided into constant and variable regions. The constant regions have the same amino acid sequences between all the immunoglobulin classes. The variable regions have approximately 110 amino acids with high sequence variability. The amino acid sequence of the heavy chain determines the class of an immunoglobulin. The five types of immunoglobulin heavy chains are known as: IgG, IgA, IgM, IgD, and IgE. IgG is divided into four subclasses, and IgA is divided into two subclasses. In serum IgA and IgG are monomers with a single 4 polypeptide unit; while, IgM is a pen tamer. IgA may also form polymers.
Kappa light chain antibody can be used for the identification of leukemias, plasmacytomas and certain non Hodgkin's lymphomas. Kappa light chain contains one immunoglobulin like domain. The EU sequence has the INV allotypic marker, Ala 45 and Val 83. The ROY sequence has the INV allotypic marker, Ala 45 and Leu 83.
|
|
|
|
|
Database links
|
The links below go to external sites and will open in a new browser window |
|
Raised in
|
Mouse
|
|
Clonality
|
Monoclonal
|
|
Clone number
|
4G7
|
|
Myeloma
|
Sp2/0
|
|
Isotype
|
IgG2a
|
|
Purity
|
Protein A purified
|
|
Storage buffer
|
Preservative: 0.1% Sodium Azide
Constituents: PBS, pH 7.4 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
|
|
Purification notes
|
Purity tested by electrophoresis.
|
|
Form
|
Liquid
|
|
Concentration
|
2.000 mg/ml
|
|
Storage instructions
|
Store at +4°C.
|
|
Notes
|
Concentration varies from lot to lot and can be provided on request.
|
| |
At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Kappa light chain antibody [4G7] is on this datasheet. But please do contact us if you would like any reassurance! |
 |
|
| |
|
Search PubMed (MEDLINE) for references to Kappa light chain
|
| |
Kappa light chain antibody [4G7] - more information
|
Customer reviews (feedback) regarding Kappa light chain antibody [4G7] |
Customer FAQs regarding Kappa light chain antibody [4G7] |
Protocols for Kappa light chain antibody [4G7] |
Price and availability of products related to Kappa light chain antibody [4G7] |
| |
Kappa light chain antibody [4G7] - related products:
|
|
|
| |
Kappa light chain antibody [4G7] - other tools:
|
Contact Abcam with a Technical Enquiry about Kappa light chain antibody [4G7] |
| |
All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Pricing information loading
