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Overview
Product name
Keap1 peptide
See all Keap1 products (2) ...
Protein description
Synthetic peptide derived from within residues 1 - 100 of Human Keap1.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab31973 - Keap1 antibody.
Protein length
624 amino acids
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Information available upon request.
Concentration
Concentration information loading...
Research areas
Epigenetics and Nuclear Signaling >> Chromatin Modifying Enzymes >> Ubiquitylation
Applications
Application notes
This peptide can be used with studies using ab31973.
Protein info
Function
Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Tissue specificity
Broadly expressed, with highest levels in skeletal muscle.
Sequence similarities
Contains 1 BACK (BTB/Kelch associated) domain.
Contains 1 BTB (POZ) domain.
Contains 6 Kelch repeats.
Domain
The Kelch repeats mediate interaction with NF2L2/NRF2, BPTF and PGAM5.
Post-translational
modifications
Ubiquitinated and subject to proteasomal degradation.
Cellular localization
Cytoplasm. Nucleus. Shuttles between cytoplasm and nucleus.
Target information above from: UniProt accessionQ14145
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
References for Keap1 peptide (ab32770)
ab32770 has not yet been referenced specifically in any publications.
Publishing research using ab32770? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"