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Anti-Keratin antibody (ab11217)

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Overview

Product name

Anti-Keratin antibody
See all Keratin products (4) ...

Description

Guinea pig polyclonal to Keratin

Specificity

ab11217 does not react with mesenchymal, glial, neuronal or muscle cells.

Tested applications

IFmore details

Cross reactivity

Reacts with

Cow, Human

Immunogen

Keratin isolated from fetal bovine hooves.

Properties

Form

Liquid

Storage instructions

Store at +4°C. Do not freeze.

Storage buffer

Preservative: 0.1% Sodium Azide
Constituents: Whole Serum

Purity

Whole antiserum

Purification notes

Affinity purified rabbit sera.

Primary antibody notes

A wide variety of cells contain, in addition to microtubules and microfilaments, another type of fibrous skeletal element which are classified under the category of "intermediate-sized" filaments. These intermediate sized filaments are stable in vivo and show a biochemical heterogeneity which is developmentally regulated. Each class of intermediate filament is restricted in vivo by tissue differentiation; keratins to epithelia, vimentin to mesenchymal cells, desmin to muscle tissues, glial fibrillary acidic protein (GFAP) to astroglia and neurofilament proteins to neurones. Unlike actin and tubulin, where molecular size is highly conserved from cell to cell and species to species, intermediate filament proteins vary greatly in size from class to class as well as species to species.

Clonality

Polyclonal

Isotype

IgG

Research areas

Signal Transduction >> Cytoskeleton / ECM >> Cytoskeleton >> Microtubules >> Cytokeratin
Signal Transduction >> Cytoskeleton / ECM >> Cytoskeleton >> Intermediate Filaments >> Class I >> Keratin
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> Structures >> Keratin
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Proteins >> Cytokeratin

Applications

Show applications key

Our Abpromise guarantee covers the use of ab11217 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • IF

     IF: 1/20

    IF: 1/20

Target

Tissue specificity

Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath.

Involvement in disease

Defects in KRT6A are a cause of pachyonychia congenita type 1 (PC1) [MIM:167200]; also known as Jadassohn-Lewandowsky syndrome. PC1 is an autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present.

Sequence similarities

Belongs to the intermediate filament family.

Target information above from: UniProt accessionP02538 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • type II cytoskeletal 6A antibody
  • 56 cytoskeletal type II keratin antibody
  • CK 6A antibody
  • CK 6B antibody
  • CK 6C antibody
  • CK-6A antibody
  • CK-6D antibody
  • CK6A antibody
  • CK6B antibody
  • CK6C antibody
  • Cytokeratin 6A antibody
  • Cytokeratin 6B antibody
  • Cytokeratin 6C antibody
  • Cytokeratin-6A antibody
  • Cytokeratin-6D antibody
  • Cytokeratin6A antibody
  • Cytokeratin6B antibody
  • Cytokeratin6C antibody
  • epidermal keratin antibody
  • K2C6A_HUMAN antibody
  • K6A antibody
  • K6a keratin antibody
  • K6B antibody
  • K6b keratin antibody
  • K6C antibody
  • K6c keratin antibody
  • Keratin 6A antibody
  • Keratin 6B antibody
  • Keratin 6C antibody
  • Keratin antibody
  • Keratin epidermal type II K6A antibody
  • Keratin epidermal type II K6B antibody
  • Keratin epidermal type II K6C antibody
  • Keratin like 1 antibody
  • Keratin type II cytoskeletal 6A antibody
  • Keratin type II cytoskeletal 6B antibody
  • Keratin type II cytoskeletal 6C antibody
  • Keratin-6A antibody
  • Keratin6A antibody
  • Keratin6B antibody
  • Keratin6C antibody
  • KRT 6A antibody
  • KRT 6B antibody
  • KRT 6C antibody
  • KRT6A antibody
  • KRT6B antibody
  • KRT6C antibody
  • KRTL 1 antibody
  • KRTL1 antibody
  • PC 2 antibody
  • PC2 antibody
  • Type II keratin isoform K6c antibody
  • Type-II keratin Kb6 antibody
see all

Database links

see all

References for Anti-Keratin antibody (ab11217)

ab11217 has not yet been referenced specifically in any publications.

Publishing research using ab11217? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"