Kidney tumor (human): Wilm's tumor tissue slides (ab4871)
Defects in WT1 are the cause of Wilms tumor 1 (WT1) [MIM:194070]. WT is an embryonal malignancy of the kidney that affects approximately 1 in 10'000 infants and young children. It occurs both in sporadic and hereditary forms.
Defects in WT1 are the cause of Denys-Drash syndrome (DDS) [MIM:194080]. DDS is a typical nephropathy characterized by diffuse mesangial sclerosis, genital abnormalities, and/or Wilms tumor. There is phenotypic overlap with WAGR syndrome and Frasier syndrome. Inheritance is autosomal dominant, but most cases are sporadic.
Defects in WT1 are the cause of nephrotic syndrome type 4 (NPHS4) [MIM:256370]. A renal disease characterized clinically by proteinuria, hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure. Most patients with NPHS4 show diffuse mesangial sclerosis on renal biopsy, which is a pathologic entity characterized by mesangial matrix expansion with no mesangial hypercellularity, hypertrophy of the podocytes, vacuolized podocytes, thickened basement membranes, and diminished patency of the capillary lumen.
Defects in WT1 are a cause of Meacham syndrome (MEACHS) [MIM:608978]. Meacham syndrome is a rare sporadically occurring multiple malformation syndrome characterized by male pseudohermaphroditism with abnormal internal female genitalia comprising a uterus and double or septate vagina, complex congenital heart defect and diaphragmatic abnormalities.
Note=A chromosomal aberration involving WT1 may be a cause of desmoplastic small round cell tumor (DSRCT). Translocation t(11;22)(p13;q12) with EWSR1.
Contains 4 C2H2-type zinc fingers.
- WIT 2 WT 1ADCC
- ADCRAWT1FWT1GUDHereditary adrenocortical carcinomaHGNC:7412MTACR1Multiple tumor associated chromosome region 1NPHS4WAGRWilms TumorWilms tumor 1Wilms tumor 2Wilms tumor 3Wilms tumor 4Wilms tumor proteinWilms' tumor geneWilms' tumor proteinWIT2WTWT 1WT1WT1_HUMANWT2WT3WT33WT4
Our Abpromise guarantee covers the use of ab4871 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||IHC-P: Use at an assay dependent concentration.|
|In Situ Hybridisation||ISH: Use at an assay dependent concentration.|
References for Kidney tumor (human): Wilm's tumor tissue slides (ab4871)
ab4871 has not yet been referenced specifically in any publications.