General notesAfter excision, tissue was fixed in paraformaldehyde and processed to paraffin wax.
Tissue sections were cut to a thickness of 5µm and mounted on positively charged glass slides.
One tissue from each lot was stained by haematoxylin and eosin (H+E) and then microscopically examined to ensure quality.
All tissue is examined / diagnosed by a licensed pathologist and is ethically obtained.
Sex and age of the donor is lot dependent. Please enquire.
FunctionActs as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.
Tissue specificityExpressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.