Kidney tumor (human): renal cell carcinoma tissue slides (ab4867)

Overview

  • Product nameKidney tumor (human): renal cell carcinoma tissue slides
  • General notesAfter excision, tissue was fixed in paraformaldehyde and processed to paraffin wax. Tissue sections were cut to a thickness of 5µm and mounted on positively charged glass slides. One tissue from each lot was stained by haematoxylin and eosin (H+E) and then microscopically examined to ensure quality. All tissue is examined / diagnosed by a licensed pathologist and is ethically obtained. Sex and age of the donor is lot dependent. Please enquire.
  • Tested applicationsIHC-P, In Situ Hybridisation more details

Properties

  • FunctionActs as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.
  • Tissue specificityExpressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.
  • Sequence similaritiesContains 10 C-type lectin domains.
    Contains 1 fibronectin type-II domain.
    Contains 1 ricin B-type lectin domain.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localizationMembrane.
  • Target information above from: UniProt accession O60449 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Alternative names
    • C-type lectin domain family 13 member B
    • CD 205
    • CD205
    • CD205 antigen
    • CLEC 13B
    • CLEC13B
    • DEC 205
    • DEC 205
    • DEC-205
    • DEC205
    • gp200
    • gp200 MR6
    • gp200 MR6
    • gp200-MR6
    • LY 75
    • Ly-75
    • LY75
    • LY75_HUMAN
    • Lymphocyte antigen 75
    • Podocalyxin
    • Renal Cell Carcinoma (gp200)
    see all

Applications

Our Abpromise guarantee covers the use of ab4867 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
IHC-P Use at an assay dependent concentration.
In Situ Hybridisation Use at an assay dependent concentration.

References for Kidney tumor (human): renal cell carcinoma tissue slides (ab4867)

ab4867 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"