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Kidney tumor (human): renal cell carcinoma tissue slides (ab4867)

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Overview

  • Product nameKidney tumor (human): renal cell carcinoma tissue slides
  • General notesAfter excision, tissue was fixed in paraformaldehyde and processed to paraffin wax. Tissue sections were cut to a thickness of 5µm and mounted on positively charged glass slides. One tissue from each lot was stained by haematoxylin and eosin (H+E) and then microscopically examined to ensure quality. All tissue is examined / diagnosed by a licensed pathologist and is ethically obtained. Sex and age of the donor is lot dependent. Please enquire.
  • Tested applicationsIHC-P, In Situ Hybridisation more details

    • Properties

  • Storage instructionsStore at +4°C.
  • Research Areas
  • FunctionActs as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.
  • Tissue specificityExpressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.
  • Sequence similaritiesContains 10 C-type lectin domains.
    Contains 1 fibronectin type-II domain.
    Contains 1 ricin B-type lectin domain.
  • Post-translational
    modifications    N-glycosylated.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession O60449 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
    • Alternative names
        C-type lectin domain family 13 member BCD 205CD205
        CD205 antigenCLEC 13BCLEC13BDEC 205DEC 205DEC-205DEC205gp200gp200 MR6gp200 MR6gp200-MR6LY 75Ly-75LY75LY75_HUMANLymphocyte antigen 75PodocalyxinRenal Cell Carcinoma (gp200)
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    Applications

    Our Abpromise guarantee covers the use of ab4867 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    IHC-P IHC-P: Use at an assay dependent concentration.
    In Situ Hybridisation ISH: Use at an assay dependent concentration.

    References for Kidney tumor (human): renal cell carcinoma tissue slides (ab4867)

    ab4867 has not yet been referenced specifically in any publications.

    Publishing research using ab4867 ? Please let us know so that we can cite the reference in this datasheet

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"