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Product Name
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L1CAM antibody [74-5H7]
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See all L1CAM antibodies (11)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [74-5H7] to L1CAM
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Immunogen
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Full length native protein (purified) (Chicken)
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Reacts with
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Chk
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Predicted to react
(species key)
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Mamm
(Due to sequence homology)
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Specificity
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The antibody binds to the L1 cytoplasmic domain at about T1172 (adjacent to the YRSL sorting signal). Phosphorylation of either T1172 or Y1176 strongly inhibits binding of 74-5H7 to the L1 cytoplasmic domain.
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Tested applications
(see key)
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IP, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IP: 1/500.
WB: 1/2000. Predicted molecular weight: 200-220 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cell membrane; Single-pass type I membrane protein.
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Research areas
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Neuroscience >> Neurology process >> Neurogenesis
Neuroscience >> Neurology process >> Growth and Development >> Axonal Guidance Proteins
Signal Transduction >> Cytoskeleton / ECM >> Cell Adhesion >> Cell Adhesion Molecules >> Liver
Neuroscience >> Cell Adhesion Proteins >> Membrane Proteins
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Relevance
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The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, adductus thumbs); and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, neural migration and in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm.
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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74-5H7
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Isotype
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IgG1
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Purity
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Ascites
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Storage buffer
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Preservative: None
Constituents: Ascites
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Form
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Liquid
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Concentration
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2.500 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this L1CAM antibody [74-5H7] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to L1CAM
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