Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Related products
- Secondary antibodies
Reassurance, Refunds & Replacements
If your product does not perform as described on this datasheet, we will refund or replace your product...
Read our guarantee »Overview
Product name
Anti-LAMP2 antibody [ABL-93] (Allophycocyanin) - Lysosome Marker
See all LAMP2 products (18) ...
Description
Rat monoclonal [ABL-93] to LAMP2 - Lysosome Marker (Allophycocyanin)
Conjugation
Allophycocyanin
Tested applications
Flow Cytmore details
Cross reactivity
Reacts with
Mouse
Immunogen
Glycoproteins purified from BALB/c mouse embryo 3T3 cell line
Properties
Form
Liquid
Storage instructions
Store at +4°C. Do not freeze.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: 16% Sucrose, PBS; Stabilizing agent
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Monoclonal
Clone number
ABL-93
Isotype
IgG2a
Light chain type
kappa
Research areas
Metabolism >> Types of disease >> Cancer
Metabolism >> Pathways and Processes >> Metabolism processes >> Autophagy and mitophagy >> Autophagosome
Metabolism >> Pathways and Processes >> Metabolic signaling pathways >> Energy transfer pathways >> Energy Metabolism
Stem Cells >> Hematopoietic Progenitors >> Myeloid >> Monocytic Lineage
Stem Cells >> Hematopoietic Progenitors >> Myeloid >> Myeloid Progenitor
Cardiovascular >> Heart >> Autophagy >> Autophagosome
Immunology >> Secreted Molecules >> Other secreted molecules
Signal Transduction >> Metabolism >> Energy Metabolism
Tags & Cell Markers >> Subcellular Markers >> Organelles >> Lysosome
Applications
Show applications key
Our Abpromise guarantee covers the use of ab25058 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Flow Cyt: Use 0.2µg for 106 cells.
Target
Function
Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter-and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.
Tissue specificity
Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is highly expressed in skeletal muscle, less in brain, placenta, lung, kidney and pancreas, very low in liver.
Involvement in disease
Defects in LAMP2 are the cause of Danon disease (DAND) [MIM:300257]; also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes.
Sequence similarities
Belongs to the LAMP family.
Post-translational
modifications
O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.
Cellular localization
Cell membrane. Endosome membrane. Lysosome membrane. This protein shuttles between lysosomes, endosomes, and the plasma membrane.
Target information above from: UniProt accessionP13473
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- CD107 antigen-like family member B antibody
- CD107b antibody
- CD107b antigen antibody
see all
Database links
- Entrez Gene: 16784 Mouse
- SwissProt: P17047 Mouse
- Unigene: 486 Mouse
References for Anti-LAMP2 antibody [ABL-93] (Allophycocyanin) - Lysosome Marker (ab25058)
ab25058 has not yet been referenced specifically in any publications.
Publishing research using ab25058? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"