Anti-LAMP2 antibody [H4B4] (Phycoerythrin) - Lysosome Marker (ab25368)

Overview

• Product nameAnti-LAMP2 antibody [H4B4] (Phycoerythrin) - Lysosome MarkerSee all LAMP2 primary antibodies ...
• Description
  Mouse monoclonal [H4B4] to LAMP2 - Lysosome Marker (Phycoerythrin)
• ConjugationPhycoerythrin
• SpecificityHuman CD107b/LAMP-2
• Tested applicationsFlow Cyt, IHC-Fr more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  The details of the immunogen for this antibody are not available.

Properties

• FormLiquid
• Storage instructionsStore at +4°C in the dark. Do not freeze.
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: 16% Sucrose, PBS; stabilizing agent
• Concentration information loading...
• PurityIgG fraction
• Clonality Monoclonal
• Clone numberH4B4
• IsotypeIgG1
• Research Areas
  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Metabolism processes
  • Autophagy and mitophagy
  • Autophagosome

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Energy transfer pathways
  • Energy Metabolism

  • Stem Cells
  • Hematopoietic Progenitors
  • Myeloid
  • Monocytic Lineage

  • Stem Cells
  • Hematopoietic Progenitors
  • Myeloid
  • Myeloid Progenitor

  • Signal Transduction
  • Metabolism
  • Energy Metabolism

  • Cardiovascular
  • Heart
  • Autophagy
  • Autophagosome

  • Tags & Cell Markers
  • Subcellular Markers
  • Organelles
  • Lysosome

  • Immunology
  • Secreted Molecules
  • Other secreted molecules

Applications

Target

• FunctionImplicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter-and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.
• Tissue specificityIsoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is highly expressed in skeletal muscle, less in brain, placenta, lung, kidney and pancreas, very low in liver.
• Involvement in diseaseDefects in LAMP2 are the cause of Danon disease (DAND) [MIM:300257]; also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes.
• Sequence similaritiesBelongs to the LAMP family.
• Post-translational
  modificationsO- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.
• Cellular localizationCell membrane. Endosome membrane. Lysosome membrane. This protein shuttles between lysosomes, endosomes, and the plasma membrane.

Target information above from: UniProt accession P13473 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 3920 Human
  • Omim: 309060 Human
  • SwissProt: P13473 Human
  • Unigene: 496684 Human

• Alternative names
  CD107 antigen-like family member B antibodyCD107b antibodyCD107b antigen antibody

  Igp110 antibodyIgp2 antibodyLAMP 2 antibodyLAMP 2C antibodyLAMP B antibodyLAMP-2 antibodyLAMP2 antibodyLAMP2_HUMAN antibodyLAMPB antibodyLGP110 antibodyLysosomal associated membrane protein 2C antibodyLysosome associated membrane glycoprotein 2 precursor antibodyLysosome associated membrane protein 2 antibodyLysosome-associated membrane glycoprotein 2 antibodyLysosome-associated membrane protein 2 antibodyMAC3 antibody

  see all