Overview

  • Product name
  • Description
    Goat polyclonal to LASP1
  • Tested applications
    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Dog
  • Immunogen

    Synthetic peptide:

    PERRDSQDGSSYR

    by a Cysteine residue linker, corresponding to internal sequence amino acids 141-153 of Human LASP1.

  • Positive control
    • Human colon and small intestine tissues; Human kidney lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab113522 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.03 - 0.1 µg/ml. Predicted molecular weight: 30 kDa.
ELISA 1/32000.
IHC-P Use a concentration of 2.5 - 5 µg/ml.

Target

  • Function
    Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
  • Sequence similarities
    Contains 1 LIM zinc-binding domain.
    Contains 2 nebulin repeats.
    Contains 1 SH3 domain.
  • Cellular localization
    Cytoplasm > cell cortex. Cytoplasm > cytoskeleton. Associated with the F-actin rich cortical cytoskeleton.
  • Information by UniProt
  • Database links
  • Alternative names
    • LASP 1 antibody
    • LASP-1 antibody
    • LASP1 antibody
    • LASP1_HUMAN antibody
    • LIM and SH3 domain protein 1 antibody
    • LIM and SH3 protein 1 antibody
    • Metastatic lymph node gene 50 protein antibody
    • MLN 50 antibody
    • MLN50 antibody
    • OTTHUMP00000164238 antibody
    • OTTHUMP00000164239 antibody
    see all

Images

  • ab113522, at 5µg/ml, staining LASP1 in Formalin-fixed, Paraffin-embedded Human Small intestine tissue by Immunohistochemistry.
  • ab113522, at 5µg/ml, staining LASP1 in Formalin-fixed, Paraffin-embedded Human Colon tissue by Immunohistochemistry.
  • Anti-LASP1 antibody (ab113522) at 0.1 µg/ml + Human Kidney lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 30 kDa

References

ab113522 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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