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Products:Signal Transduction >> Metabolism >> Lipid metabolism
Overview
Product name
Anti-LASS2 antibody
See all LASS2 products (3) ...
Description
Mouse monoclonal to LASS2
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Recombinant full length protein, corresponding to amino acids 1-381 of Human LASS2
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: Ascites
Concentration
Concentration information loading...
Purity
Ascites
Clonality
Monoclonal
Light chain type
lambda
Research areas
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Cancer >> Oncoproteins/suppressors >> Tumor suppressors >> Other
Signal Transduction >> Metabolism >> Lipid metabolism
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Western blot - LASS2 antibody (ab57136)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab57136 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
Application notes
WB: Use at a dilution 1/500 - 1/1000.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
LASS2 (LAG1 homolog, ceramide synthase 2) has sequence similarity to yeast longevity assurance gene 1. It is thought to be involved in sphingolipid synthesis. Expression of LASS2 is transiently increased during the period of active myelination and is specifically localized to white matter tracts of the brain, including the Schwann cells of sciatic nerves suggesting that LASS2 is important for the synthesis of dihydroceramide used for synthesis of myelin sphingolipids. Expression of LASS2 in hepatocellular carcinoma cell lines suppresses the growth of cancer cells.
Cellular localization
Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Alternative names
- CerS 2 antibody
- CerS2 antibody
- FLJ10243 antibody
see all
Database links
- Entrez Gene: 29956 Human
- Omim: 606920 Human
- SwissProt: Q96G23 Human
- Unigene: 713103 Human
Anti-LASS2 antibody images:
Western blot - LASS2 antibody (ab57136)
Anti-LASS2 antibody (ab57136) + immunogen
Observed band size : 70 kDa (why is the actual band size different from the predicted?)
The observed protein size may not correspond to the predicted molecular weight as the immunogen was used for the test lane.
References for Anti-LASS2 antibody (ab57136)
ab57136 has not yet been referenced specifically in any publications.
Publishing research using ab57136? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"