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Products:Signal Transduction >> Metabolism >> Lipid metabolism
Overview
Product name
Anti-LASS2 antibody
See all LASS2 products (3) ...
Description
Rabbit polyclonal to LASS2
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide derived from human LASS2 protein
Positive control
Liver and Kidney. Human placenta lysate
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.08% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Ammonium Sulphate Precipitation
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Cancer >> Oncoproteins/suppressors >> Tumor suppressors >> Other
Signal Transduction >> Metabolism >> Lipid metabolism
Applications
Show applications key
Our Abpromise guarantee covers the use of ab81253 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 - 5 µg/ml.Predicted molecular weight: 45 kDa.
Target
Relevance
LASS2 (LAG1 homolog, ceramide synthase 2) has sequence similarity to yeast longevity assurance gene 1. It is thought to be involved in sphingolipid synthesis. Expression of LASS2 is transiently increased during the period of active myelination and is specifically localized to white matter tracts of the brain, including the Schwann cells of sciatic nerves suggesting that LASS2 is important for the synthesis of dihydroceramide used for synthesis of myelin sphingolipids. Expression of LASS2 in hepatocellular carcinoma cell lines suppresses the growth of cancer cells.
Cellular localization
Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Alternative names
- CerS 2 antibody
- CerS2 antibody
- FLJ10243 antibody
see all
Database links
- Entrez Gene: 29956 Human
- Omim: 606920 Human
- SwissProt: Q96G23 Human
- Unigene: 713103 Human
References for Anti-LASS2 antibody (ab81253)
ab81253 has not yet been referenced specifically in any publications.
Publishing research using ab81253? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"