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Overview

  • Product nameLD78 beta protein (Active)See all LD78 beta proteins and peptides ...
  • Protein descriptionRecombinant full length mature Pig LD78 beta (amino acids 24-93) expressed in yeast; 70 amino acids, Predicted MWt 7.8 kDa (TrEMBL Q6DUK4).
  • Expression hostSaccharomyces cerevisiae

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Purification notesab87908 was purified using Ion-exchange chromatography
  • Biological activityThe biological activity of ab87908 was determined in a chemotaxis assay using a Boyden chamber with freshly isolated swine PBMC monocytes using a Percoll gradient enrichment method. Biological activity typically peaks at 100 ng/mL.
  • FormLyophilised:Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein. Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C.
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.This product is an active protein and may elicit a biological response in vivo, handle with caution.
  • Storage bufferPreservative: None
    Constituents: 10% Trehalose, 1X PBS
  • Concentration information loading...
  • Sequence notesAPLGADTPTA CCFSYTSRQL PRKFVADYFE TSSQCSKPGV IFQTKKGREV CANPEDAWVQ EYISDLELNA
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab87908 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.
    Functional Studies FuncS: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        464.2C C motif chemokine 3 like 1CCL3L1
        CCL3L3Chemokine (C C motif) ligand 3 like 1Chemokine (C C motif) ligand 3 like 3Chemokine (C C motif) ligand 3 like, centromericchemokine (CC motif) ligand 3 like 1CL3L1_HUMAND17S1718G0/G1 switch regulatory protein 19-2G0S19-2LD78LD78 beta(1-70)LD78-beta(1-70)LD78-beta(5-70)LD78BETAMGC104178MGC12815MGC182017MIP1APPAT 464.2SCYA3LSCYA3L1Small inducible cytokine A3 like 1 precursorSmall-inducible cytokine A3-like 1Tonsillar lymphocyte LD78 betaTonsillar lymphocyte LD78 beta protein
      see all
  • FunctionChemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.
  • Sequence similaritiesBelongs to the intercrine beta (chemokine CC) family.
  • Post-translational
    modifications    The N-terminal processed forms LD78-beta(3-70) and LD78-beta(5-70) are produced by proteolytic cleavage after secretion from peripheral blood monocytes. The cleavage to yield LD78-beta(3-70) is probably achieved by DPP4.
  • Cellular localizationSecreted.

    • Target information above from: UniProt accession P16619 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for LD78 beta protein (Active) (ab87908)

    ab87908 has not yet been referenced specifically in any publications.

    Publishing research using ab87908 ? Please let us know so that we can cite the reference in this datasheet

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