LDB3 peptide (251-262) (ab45811)

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Product Name

LDB3 peptide (251-262)

Product type

Proteins and Peptides

Peptide

Synthetic peptide: KSQNKPEDEADE, corresponding to amino acids 251-262 of Human LDB3
This peptide was used as an immunogen for ab40840 - LDB3 antibody.
BLAST 'KSQNKPEDEADE' with or

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Research areas

Signal Transduction >> Adapters >> Cytoplasmic

Relevance

LDB3 (LIM domain-binding protein 3) may function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. It interactes with various PKC isoforms and with the C-terminal region of ACTN2 via its LIM and PDZ domains respectively. It also interacts with MYOZ1, MYOZ2 and MYOZ3. 6 isoforms are produced by alternative splicing. Defects in LDB3 are a cause of dilated cardiomyopathy 1A, a disorder characterized by cardiac dilation and reduced systolic function, as well as ZASP-related myofibrillar myopathy, an autosomal dominant myopathy that is characterized by distal muscle weakness with signs of cardiomyopathy and neuropathy.

Alternative names LDB3 peptide (251-262) (ab45811)

Form

Liquid

Concentration

1.000 mg/ml

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

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