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Products:Signal Transduction >> Protein Trafficking >> ER Proteins
Overview
Product name
LMAN1 peptide (159-173 )
Protein description
Synthetic peptide: FDSFDNDGKKNNPAI , corresponding to amino acids 159-173 of Rat LMAN1 This peptide was used as an immunogen for ab32583 - LMAN1 antibody.
Properties
Purification notes
HPLC purity tested, >70% pure.
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Concentration
Concentration information loading...
Sequence
FDSFDNDGKK NNPAI
Research areas
Signal Transduction >> Protein Trafficking >> Golgi Proteins
Signal Transduction >> Protein Trafficking >> ER Proteins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab39824 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Neut: Use at an assay dependent dilution.
Protein info
Function
Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.
Tissue specificity
Ubiquitous.
Involvement in disease
Defects in LMAN1 are THE cause of factor V and factor VIII combined deficiency type 1 (F5F8D1) [MIM:227300]; also known as multiple coagulation factor deficiency I (MCFD1). F5F8D1 is an autosomal recessive blood coagulation disorder characterized by bleeding symptoms similar to those in hemophilia or parahemophilia, that are caused by single deficiency of FV or FVIII, respectively. The most common symptoms are epistaxis, menorrhagia, and excessive bleeding during or after trauma. Plasma levels of coagulation factors V and VIII are in the range of 5 to 30% of normal.
Sequence similarities
Contains 1 L-type lectin-like domain.
Post-translational
modifications
The N-terminal may be partly blocked.
Cellular localization
Endoplasmic reticulum-Golgi intermediate compartment membrane. Golgi apparatus membrane. Endoplasmic reticulum membrane.
Target information above from: UniProt accessionP49257
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
References for LMAN1 peptide (159-173 ) (ab39824)
ab39824 has not yet been referenced specifically in any publications.
Publishing research using ab39824? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"