Overview

  • Product name
    Anti-LMBR1 antibody
  • Description
    Rabbit polyclonal to LMBR1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Chicken, Cow, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 1-50 (MEGQDEVSAR EQHFHSQVRE STICFLLFAI LYVVSYFIIT RYKRKSDEQE) of Human LMBR1 (NP_071903).

  • Positive control
    • HepG2 cell lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab106323 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.25 µg/ml. Predicted molecular weight: 55 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    Putative membrane receptor.
  • Tissue specificity
    Widely expressed with strongest expression in heart and pancreas.
  • Involvement in disease
    Defects in LMBR1 are associated with preaxial polydactyly type 2 (PPD2) [MIM:174500]; also known as polydactyly of triphalangeal thumb. Polydactyly consists of duplication of the distal phalanx. The thumb in PPD2 is usually opposable and possesses a normal metacarpal. The mutations do not change the normal expression of LMBR1, but alter the expression of SHH by disrupting a long-range, cis-regulatory element of that gene.
    Defects in LMBR1 are the cause of acheiropody (ACHP) [MIM:200500]. Acheiropody is a very rare condition characterized by bilateral congenital amputations of the hands and feet. The specific malformative phenotype consists of a complete amputation of the distal epiphysis of the humerus, amputation of the tibial diaphysis, and aplasia of the radius, ulna, fibula, and of all the bones of the hands and feet. This syndrome of autosomal recessive inheritance has only been observed in Brazil so far.
    Defects in LMBR1 are a cause of syndactyly type 4 (SDYT4) [MIM:186200]. SDYT4 is a very rare congenital distal limb malformation characterized by complete bilateral syndactyly (involving all digits 1 to 5). A frequent association with polydactyly (with six metacarpals and six digits) has been reported. Feet are affected occasionally. The condition is inherited as an autosomal dominant trait.
  • Sequence similarities
    Belongs to the LIMR family.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ACHP antibody
    • C7orf2 antibody
    • DIF 14 antibody
    • DIF14 antibody
    • Differentiation related gene 14 antibody
    • Differentiation related gene 14 protein antibody
    • Differentiation-related gene 14 protein antibody
    • FLJ11665 antibody
    • Limb region 1 homolog (mouse) antibody
    • Limb region 1 homolog antibody
    • Limb region 1 protein antibody
    • Limb region 1 protein homolog antibody
    • LMBR 1 antibody
    • LMBR1 antibody
    • LMBR1_HUMAN antibody
    • OTTHUMP00000211720 antibody
    • PPD 2 antibody
    • PPD2 antibody
    • TPT antibody
    see all

Images

  • Anti-LMBR1 antibody (ab106323) at 0.25 µg/ml + HepG2 cell lysate at 10 µg

    Predicted band size : 55 kDa

References

ab106323 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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