You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab57329 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use a concentration of 1 - 5 µg/ml. This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

Target

  • FunctionMay play a role in the phosphorylation of proteins central to Parkinson disease. Phosphorylates PRDX3. May also have GTPase activity. Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes.
  • Tissue specificityExpressed throughout the adult brain, but at a lower level than in heart and liver. Also expressed in placenta, lung, skeletal muscle, kidney and pancreas. In the brain, expressed in the cerebellum, cerebral cortex, medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen. Expression is particularly high in brain dopaminoceptive areas.
  • Involvement in diseaseParkinson disease 8 (PARK8) [MIM:607060]: A slowly progressive neurodegenerative disorder characterized by bradykinesia, rigidity, resting tremor, postural instability, neuronal loss in the substantia nigra, and the presence of neurofibrillary MAPT (tau)-positive and Lewy bodies in some patients. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
    Contains 12 LRR (leucine-rich) repeats.
    Contains 1 protein kinase domain.
    Contains 1 Roc domain.
  • Post-translational
    modifications    Autophosphorylated.
  • Cellular localizationCytoplasm. Membrane. Mitochondrion. Localized in the cytoplasm and associated with cellular membrane structures. Associates with the mitochondrial outer membrane.

    • Target information above from: UniProt accession Q5S007 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        augmented in rheumatoid arthritis 17 antibodyAURA17 antibodyDardarin antibody
        Leucine rich repeat kinase 2 antibodyLeucine-rich repeat serine/threonine-protein kinase 2 antibodyLRRK 2 antibodyLRRK2 antibodyLRRK2_HUMAN antibodyPARK 8 antibodyPARK8 antibodyRIPK7 antibodyROCO 2 antibodyROCO2 antibody
      see all

    Anti-LRRK2 antibody images

    • Western blot - LRRK2 antibody (ab57329)
      Western blot - LRRK2 antibody (ab57329)
      Western blot against tagged recombinant protein immunogen using ab57329 LRRK2 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-LRRK2 antibody (ab57329)

    ab57329 has not yet been referenced specifically in any publications.

    Publishing research using ab57329 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit an Abreview for ab57329 Submit a Question for ab57329

    There are currently no Abreviews or Questions for ab57329.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"