Anti-LTBP4 antibody (ab97860)

Overview

• Product nameAnti-LTBP4 antibody
• Description
  Rabbit polyclonal to LTBP4
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat
• Immunogen

  Recombinant protein fragment corresponding to a region within amino acids 64 and 256 of LTBP4 (NP_003564).

• Positive controlA549, HeLa, Jurkat or NT2D1 cell lysate.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.01% Thimerosal (merthiolate)
  Constituents: 20% Glycerol, 1% BSA, 1X PBS, pH 7
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Cancer
  • Growth factors
  • TGF

  • Signal Transduction
  • Growth Factors/Hormones
  • TGF

  • Signal Transduction
  • Cytoskeleton / ECM
  • Extracellular Matrix
  • ECM Proteins
  • Other ECM Proteins

  • Cardiovascular
  • Angiogenesis
  • Growth Factors
  • TGF

Applications

Target

• FunctionMay be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM).
• Tissue specificityHighly expressed in heart, skeletal muscle, pancreas, uterus, and small intestine. Weakly expressed in placenta and lung.
• Involvement in diseaseDefects in LTBP4 are the cause of Urban-Rifkin-Davis syndrome (URDS) [MIM:613177]; also known as Cutis laxa with severe pulmonary gastrointestinal and urinary abnormalities. URDS is a syndrome characterized by disrupted pulmonary, gastrointestinal, urinary, musculoskeletal, craniofacial and dermal development. Clinical features include cutis laxa, mild cardiovascular lesions, respiratory distress with cystic and atelectatic changes in the lungs, and diverticulosis, tortuosity and stenosis at various levels of the intestinal tract. Craniofacial features include microretrognathia, flat midface, receding forehead and wide fontanelles.
• Sequence similaritiesBelongs to the LTBP family.
  Contains 16 EGF-like domains.
  Contains 4 TB (TGF-beta binding) domains.
• Developmental stageVery low expression in fetal brain, liver, heart, spleen and thymus.
• Post-translational
  modificationsContains hydroxylated asparagine residues.
• Cellular localizationSecreted > extracellular space > extracellular matrix.

Target information above from: UniProt accession Q8N2S1 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 8425 Human
  • Entrez Gene: 108075 Mouse
  • Entrez Gene: 292734 Rat
  • Omim: 604710 Human
  • SwissProt: Q8N2S1 Human
  • SwissProt: Q8K4G1 Mouse
  • Unigene: 466766 Human
  • Unigene: 272251 Mouse

• Alternative names
  latent transforming growth factor beta binding protein 4 antibodylatent transforming growth factor beta binding protein 4L antibodyLatent-transforming growth factor beta-binding protein 4 antibody

  LTBP 4 antibodyLTBP-4 antibodyLTBP4 antibodyLTBP4_HUMAN antibodyLTBP4L antibodyLTBP4S antibody

  see all

Anti-LTBP4 antibody images

• 

  Western blot - LTBP4 antibody (ab97860)
  All lanes : Anti-LTBP4 antibody (ab97860) at 1/1000 dilution
  
  Lane 1 : HeLa whole cell lysate
  Lane 2 : Jurkat whole cell lysate
  
  Lysates/proteins at 30 µg per lane.
  
  
  Predicted band size : 173 kDa