Anti-LTBR antibody (ab70063)
Key features and details
- Rabbit polyclonal to LTBR
- Suitable for: WB, ICC/IF
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-LTBR antibody
See all LTBR primary antibodies -
Description
Rabbit polyclonal to LTBR -
Host species
Rabbit -
Tested applications
Suitable for: WB, ICC/IFmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide derived from an internal region of human LTBR.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, PBS
Without Mg2+ and Ca2+ -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Conjugation kits
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab70063 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (1) |
1/500 - 1/1000. Detects a band of approximately 50 kDa (predicted molecular weight: 48 kDa).
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ICC/IF |
1/500 - 1/1000.
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Notes |
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WB
1/500 - 1/1000. Detects a band of approximately 50 kDa (predicted molecular weight: 48 kDa). |
ICC/IF
1/500 - 1/1000. |
Target
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Function
Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. -
Sequence similarities
Contains 4 TNFR-Cys repeats. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 4055 Human
- Omim: 600979 Human
- SwissProt: P36941 Human
- Unigene: 1116 Human
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Alternative names
- CD18 antibody
- D12S370 antibody
- LT beta R antibody
see all
Images
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All lanes : Anti-LTBR antibody (ab70063) at 1/500 dilution
Lane 1 : HeLa cell extract
Lane 2 : HepG2 cell extract
Lane 3 : HeLa cell extract with immunising peptide at 5 µg
Lysates/proteins at 5 µg per lane.
Predicted band size: 48 kDa
Observed band size: 50 kDa why is the actual band size different from the predicted?
Additional bands at: 22 kDa. We are unsure as to the identity of these extra bands. -
HeLa cells with ab70063 at 1/500 dilution, with and without the immunising peptide.
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (6)
ab70063 has been referenced in 6 publications.
- Hu Z & Zhou G CREB1 Transcriptionally Activates LTBR to Promote the NF-κB Pathway and Apoptosis in Lung Epithelial Cells. Comput Math Methods Med 2022:9588740 (2022). WB ; Human . PubMed: 36118831
- Schmidt M et al. Stimulation of Non-canonical NF-κB Through Lymphotoxin-β-Receptor Impairs Myogenic Differentiation and Regeneration of Skeletal Muscle. Front Cell Dev Biol 9:721543 (2021). PubMed: 34676210
- Choi SY et al. YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells. Nat Commun 11:519 (2020). PubMed: 31980640
- Francipane MG et al. Host Lymphotoxin-ß Receptor Signaling Is Crucial for Angiogenesis of Metanephric Tissue Transplanted into Lymphoid Sites. Am J Pathol 190:252-269 (2020). PubMed: 31585070
- Ling X et al. Lymphotoxin beta receptor is associated with regulation of microRNAs expression and nuclear factor-kappa B activation in lipopolysaccharides (LPS)-stimulated vascular smooth muscle cells. Ann Palliat Med 9:805-815 (2020). PubMed: 32279515
- Shen M et al. Lymphotoxin ß receptor activation promotes bladder cancer in a nuclear factor-?B-dependent manner. Mol Med Rep 11:783-90 (2015). IHC-P ; Human . PubMed: 25369740