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Product name
LY 294002
Description
PI-3 kinase inhibitor
Biological description
A highly selective inhibitor of phosphatidylinositol 3-kinase (IC50 = 1.4 μM). Selective over a range of other kinases including protein kinase C, protein kinase A, MAP kinase and PI-4 kinase (IC50 > 50 μM).
Purity
> 99%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one
Molecular Weight
307.35
Chemical structure
Molecular formula
C19H17NO3
CAS Number
154447-36-6
Solubility
Soluble in DMSO to 25 mM and in ethanol to 5 mM
Storage instructions
Store at +4°C (desiccating conditions). Do not freeze.
Research areas
Biochemicals >> Research Area >> Stroke >> Signaling >> Lipid signaling >> PI3-kinase >> Inhibitors
Biochemicals >> Research Area >> Respiratory disease >> Signaling >> Lipid signaling >> PI3-kinase >> Inhibitors
Biochemicals >> Research Area >> Pain & inflammation >> Signaling >> Lipid signaling >> PI3-kinase >> Inhibitors
Biochemicals >> Research Area >> Obesity >> Signaling >> Lipid signaling >> PI3-kinase >> Inhibitors
Biochemicals >> Research Area >> Hypertension >> Signaling >> Lipid signaling >> PI3-kinase >> Inhibitors
Biochemicals >> Research Area >> Heart disease >> Signaling >> Lipid signaling >> PI3-kinase >> Inhibitors
Biochemicals >> Research Area >> Diabetes >> Signaling >> Lipid signaling >> PI3-kinase >> Inhibitors
Biochemicals >> Research Area >> Cancer >> Signaling >> Lipid signaling >> PI3-kinase >> Inhibitors
Biochemicals >> Research Area >> Alzheimer's Disease >> Signaling >> Lipid signaling >> PI3-kinase >> Inhibitors
Biochemicals >> Pharmacology >> Signaling >> Lipid signaling >> PI3-kinase >> Inhibitors
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> PI3-kinase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
References for LY 294002 (ab120243)
This product has been referenced in:
- Gharbi SI et al. Exploring the specificity of the PI3K family inhibitor LY294002. Biochem J 404:15-21 (2007).Read more (PubMed: 17302559) »
- Walker EH et al. Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol Cell 6:909-19 (2000).Read more (PubMed: 11090628) »
See all 3 publications for this product
Publishing research using ab120243? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"