AbcamBiochemicals

LY 341495 sodium salt (ab120400)

Overview

  • Product nameLY 341495 sodium salt
  • Description
    Water-soluble, potent, selective group II antagonist. Group III antagonist at higher concentrations.
  • Biological descriptionWater-soluble form of the very selective nanomolar potent antagonist for group II mGlu receptors. Also a relatively potent antagonist for group III mGlu receptors at high nanomolar to low micromolar concentrations. Kd values are 1.67 (human mGlu2), 0.75 (mGlu3), 31.6 (mGlu6), 72.7 (mGlu7a) and 14 nM (human mGlu8a ). IC50 values are 7.8, 8.2 and 22 μM for mGlu1a, mGlu5a and mGlu4 receptors, respectively. Readily brain penetrant and active in vivo.
    A more readily water soluble version is also available (ab120818)
  • Purity> 98%
  • General notes

    Sold under license from Eli Lilly and company

Properties

    References for LY 341495 sodium salt (ab120400)

    This product has been referenced in:
    • Linden AM  et al. Use of MGLUR2 and MGLUR3 knockout mice to explore in vivo receptor specificity of the MGLUR2/3 selective antagonist LY341495. Neuropharmacology 57:172-82 (2009). Read more (PubMed: 19477188) »
    • Wright RA  et al. Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol 362:546-54 (2000). Read more (PubMed: 11138847) »
    • Johnson BG  et al. [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells. Neuropharmacology 38:1519-29 (1999). Read more (PubMed: 10530814) »
    • Kingston AE  et al. LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors. Neuropharmacology 37:1-12 (1998). Read more (PubMed: 9680254) »

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