AbcamBiochemicals

LY 341495 sodium salt (ab120400)

Overview

  • Product nameLY 341495 sodium salt
  • Description
    Water-soluble, potent, selective group II antagonist. Group III antagonist at higher concentrations.
  • Biological descriptionWater-soluble form of the very selective nanomolar potent antagonist for group II mGlu receptors. Also a relatively potent antagonist for group III mGlu receptors at high nanomolar to low micromolar concentrations. Kd values are 1.67, 0.75, 31.6, 72.7, 14 nM at human mGlu2, mGlu3, mGlu6 , mGlu7a, and human mGlu8a receptors respectively. IC50 values are 7.8, 8.2 and 22 μM for mGlu1a, mGlu5a and mGlu4 receptors. Readily brain penetrant and active in vivo.
  • Purity> 98%
  • General notes

    Sold under license from Eli Lilly and company

Properties

    References for LY 341495 sodium salt (ab120400)

    This product has been referenced in:
    • Linden AM  et al. Use of MGLUR2 and MGLUR3 knockout mice to explore in vivo receptor specificity of the MGLUR2/3 selective antagonist LY341495. Neuropharmacology 57:172-82 (2009). Read more (PubMed: 19477188) »
    • Wright RA  et al. Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol 362:546-54 (2000). Read more (PubMed: 11138847) »
    • Johnson BG  et al. [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells. Neuropharmacology 38:1519-29 (1999). Read more (PubMed: 10530814) »
    • Kingston AE  et al. LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors. Neuropharmacology 37:1-12 (1998). Read more (PubMed: 9680254) »

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