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- Secondary antibodies
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Product name
Anti-LYVE1 antibody
See all LYVE1 products (8) ...
Description
Rabbit polyclonal to LYVE1
Specificity
This antibody is the immunogen affinity purified version of ab10278.
Tested applications
ELISA, WB, IHC-P, IHC-Fr, Flow Cytmore details
Cross reactivity
Reacts with
Human
Immunogen
Recombinant human soluble LYVE1.
Properties
Form
Lyophilised:
Please reconstitue with 100ul sterile water.
When reconstituted in sterile water to a concentration of >0.5 mg/ml the antibody is stable for at least six weeks at 2-4°C.
Storage instructions
Shipped at 4°C. Store at -20ºC.
Storage buffer
Preservative: None
Constituents: PBS, pH 7.4
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Applications
Show applications key
Our Abpromise guarantee covers the use of ab36993 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA: Use a concentration of 1 - 15 µg/ml.
WB: Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 35 kDa.
IHC-P: Use a concentration of 1 - 5 µg/ml.
IHC-Fr: Use a concentration of 1 - 5 µg/ml.
Flow Cyt: Use a concentration of 3 - 20 µg/ml.
Target
Function
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
Tissue specificity
Mainly expressed in endothelial cells lining lymphatic vessels.
Sequence similarities
Contains 1 Link domain.
Post-translational
modifications
O-glycosylated.
Cellular localization
Membrane. Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface.
Target information above from: UniProt accessionQ9Y5Y7
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Cell surface retention sequence-binding protein 1 antibody
- CRSBP 1 antibody
- CRSBP-1 antibody
see all
Database links
- Entrez Gene: 10894 Human
- Omim: 605702 Human
- SwissProt: Q9Y5Y7 Human
- Unigene: 246769 Human
- Unigene: 655332 Human
Anti-LYVE1 antibody images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - LYVE1 antibody (ab36993)
IHC with paraffin-embedded sections of human intestine (border area of a colon carcinoma) using antibody ab36993.
Immunohistochemistry (Frozen sections) - LYVE1 antibody (ab36993)
The staining was performed on frozen sections from human colon carcinoma using ab36993 (polyclonal anti-human LYVE-1 antibody; protein-A purified; 10 μg/ml).
References for Anti-LYVE1 antibody (ab36993)
This product has been referenced in:
- Cueni LN et al. Podoplanin-Fc reduces lymphatic vessel formation in vitro and in vivo and causes disseminated intravascular coagulation when transgenically expressed in the skin. Blood 116:4376-84 (2010). IHC; Mouse.Read more (PubMed: 20716773) »
- Zhang SQ et al. Clinical implications of increased lymph vessel density in the lymphatic metastasis of early-stage invasive cervical carcinoma: a clinical immunohistochemical method study. BMC Cancer 9:64 (2009). IHC-P; Human.Read more (PubMed: 19232130) »
See all 3 publications for this product
Publishing research using ab36993? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"