Overview

  • Product name
    Lamotrigine
  • Description
    Anticonvulsant
  • Biological description
    Anticonvulsant. Active in vivo and orally bioavailable. Various pharmacological activities including sodium channel blocking (Ki = 9 μM). Selectively inhibits seizure discharges over normal neuronal activity.
  • Purity
    > 98%

Properties

  • Chemical name
    6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
  • Molecular weight
    255.01
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C9H7Cl2N5
  • CAS Number
    84057-84-1
  • PubChem identifier
    3878
  • Storage instructions
    Store at -20°C. It is important to note that this is air sensitive and impurities can occur as a result of air oxidation. Store under desiccating conditions.
  • Solubility overview
    Soluble in DMSO to 25 mM (with warming) and in ethanol to 25 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C(N=N2)N)N
  • Source

    Synthetic

  • Research areas

    References for Lamotrigine (ab142527)

    This product has been referenced in:
    • Lukawski K  et al. Effect of hydrochlorothiazide on the anticonvulsant action of antiepileptic drugs against maximal electroshock-induced seizures in mice. Pharmacol Rep 64:315-20 (2012). Read more (PubMed: 22661181) »
    • Kuo CC & Lu L Characterization of lamotrigine inhibition of Na+ channels in rat hippocampal neurones. Br J Pharmacol 121:1231-8 (1997). Read more (PubMed: 9249262) »
    • Getova DP & Mihaylova AS A study of the effects of lamotrigine on mice using two convulsive tests. Folia Med (Plovdiv) 53:57-62 (0). Read more (PubMed: 21797108) »

    See 0 Publications for this product

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