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Anti-Leptin antibody [4F12] (ab6057)

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Overview

Product name

Anti-Leptin antibody [4F12]
See all Leptin products (25) ...

Description

Mouse monoclonal [4F12] to Leptin

Specificity

Recognizes recombinant human leptin and leptin circulating in human blood.

Tested applications

Sandwich ELISA, ELISAmore details

Cross reactivity

Reacts with

Human

Immunogen

Recombinant full length protein.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: 0.1% Sodium Azide
Constituents: PBS, pH 7.4

Concentration

Concentration information loading...

Purity

Protein A purified

Clonality

Monoclonal

Clone number

4F12

Myeloma

Sp2/0

Isotype

IgG1

Research areas

Metabolism >> Types of disease >> Heart disease
Metabolism >> Types of disease >> Cancer
Metabolism >> Types of disease >> Obesity
Cardiovascular >> Atherosclerosis >> Diabetes associated
Stem Cells >> Mesenchymal Stem Cells >> Adipogenesis
Neuroscience >> Neurology process >> Metabolism
Signal Transduction >> Growth Factors/Hormones >> Hormones

Applications

Show applications key

Our Abpromise guarantee covers the use of ab6057 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.

Involvement in disease

Defects in LEP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.

Sequence similarities

Belongs to the leptin family.

Cellular localization

Secreted.

Target information above from: UniProt accessionP41159 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Obesity factor antibody
  • FLJ94114 antibody
  • LEP antibody
  • LEP_HUMAN antibody
  • Leptin (murine obesity homolog) antibody
  • Leptin (obesity homolog, mouse) antibody
  • Leptin antibody
  • Leptin Murine Obesity Homolog antibody
  • Leptin Precursor Obesity Factor antibody
  • OB antibody
  • Obese Protein antibody
  • Obese, mouse, homolog of antibody
  • Obesity antibody
  • Obesity factor antibody
  • Obesity homolog mouse antibody
  • Obesity Murine Homolog Leptin antibody
  • OBS antibody
  • OTTHUMP00000212285 antibody
see all

Database links

References for Anti-Leptin antibody [4F12] (ab6057)

ab6057 has not yet been referenced specifically in any publications.

Publishing research using ab6057? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"