Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Reassurance, Refunds & Replacements
If your product does not perform as described on this datasheet, we will refund or replace your product...
Read our guarantee »Overview
Product name
Anti-Leptin antibody [4F8]
See all Leptin products (25) ...
Description
Mouse monoclonal [4F8] to Leptin
Specificity
This antibody recognizes recombinant human leptin and leptin circulating in human blood.
Tested applications
ELISAmore details
Cross reactivity
Reacts with
Human
Immunogen
Recombinant full length protein.
General notes
Concentration varies from lot to lot and can be provided on request.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: PBS, pH 7.4
Concentration
Concentration information loading...
Purity
Protein A purified
Purification notes
Purity is tested by electrophoresis.
Clonality
Monoclonal
Clone number
4F8
Myeloma
Sp2/0
Isotype
IgG1
Research areas
Metabolism >> Types of disease >> Heart disease
Metabolism >> Types of disease >> Cancer
Metabolism >> Types of disease >> Obesity
Cardiovascular >> Atherosclerosis >> Diabetes associated
Stem Cells >> Mesenchymal Stem Cells >> Adipogenesis
Neuroscience >> Neurology process >> Metabolism
Signal Transduction >> Growth Factors/Hormones >> Hormones
Applications
Show applications key
Our Abpromise guarantee covers the use of ab1976 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA
Application notes
ELISA: Use at an assay dependent dilution.
This antibody was tested in sandwich ELISA as capture and detection antibodies with human blood samples. This antibody detects antigen in human blood with high sensitivity.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
Involvement in disease
Defects in LEP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
Sequence similarities
Belongs to the leptin family.
Cellular localization
Secreted.
Target information above from: UniProt accessionP41159
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Obesity factor antibody
- FLJ94114 antibody
- LEP antibody
see all
Database links
- Entrez Gene: 3952 Human
- Omim: 164160 Human
- SwissProt: Q6NT58 Human
- SwissProt: P41159 Human
- SwissProt: P48357 Human
- Unigene: 194236 Human
References for Anti-Leptin antibody [4F8] (ab1976)
ab1976 has not yet been referenced specifically in any publications.
Publishing research using ab1976? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"