- Product nameLevcromakalim
- DescriptionKATP channel activator.
- Biological descriptionPowerful smooth muscle relaxant. Acts by direct activation of ATP-sensitive K+ channels. Active enantiomer of cromakalim (ab120486). EC50 = 1.6 μM as measured in rat intracardiac ganglia neurones.
- Purity> 99%
- Chemical name(3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
- Molecular Weight286.33
- Chemical structure
- Molecular formulaC16H18N2O3
- CAS Number94535-50-9
- Storage instructionsStore at +4°C (desiccating conditions).
- Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 25 mM (with warming)
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for Levcromakalim (ab120485)
This product has been referenced in:
- Brayden JE Functional roles of KATP channels in vascular smooth muscle. Clin Exp Pharmacol Physiol 29:312-6 (2002). Read more (PubMed: 11985542) »
- Hogg RC & Adams DJ An ATP-sensitive K(+) conductance in dissociated neurones from adult rat intracardiac ganglia. J Physiol 534:713-20 (2001). Read more (PubMed: 11483702) »
- Bowring NE et al. Comparison of the airways relaxant and hypotensive potencies of the potassium channel activators BRL 55834 and levcromakalim (BRL 38227) in vivo in guinea-pigs and rats. Br J Pharmacol 109:1133-9 (1993). Read more (PubMed: 8401925) »
- Taylor SG et al. The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways: comparison with pinacidil and verapamil. J Pharmacol Exp Ther 261:429-37 (1992). Read more (PubMed: 1578358) »