AbcamBiochemicals

Levcromakalim (ab120485)

Overview

  • Product nameLevcromakalim
  • Description
    KATP channel activator
  • Biological descriptionPowerful smooth muscle relaxant. Acts by direct activation of ATP-sensitive K+ channels. Active enantiomer of cromakalim (ab120486). EC50 = 1.6 μM as measured in rat intracardiac ganglia neurones.
  • Purity> 99%

Properties

    References for Levcromakalim (ab120485)

    This product has been referenced in:
    • Brayden JE Functional roles of KATP channels in vascular smooth muscle. Clin Exp Pharmacol Physiol 29:312-6 (2002). Read more (PubMed: 11985542) »
    • Hogg RC & Adams DJ An ATP-sensitive K(+) conductance in dissociated neurones from adult rat intracardiac ganglia. J Physiol 534:713-20 (2001). Read more (PubMed: 11483702) »
    • Bowring NE  et al. Comparison of the airways relaxant and hypotensive potencies of the potassium channel activators BRL 55834 and levcromakalim (BRL 38227) in vivo in guinea-pigs and rats. Br J Pharmacol 109:1133-9 (1993). Read more (PubMed: 8401925) »
    • Taylor SG  et al. The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways: comparison with pinacidil and verapamil. J Pharmacol Exp Ther 261:429-37 (1992). Read more (PubMed: 1578358) »

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    As far as I am aware from our records, there should be no import restrictions and cromakalim[ab120486], and lev cromakalim [ab120485] are available in India.

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