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Product name
Lovastatin (Mevinolin)
Description
Potent HMG CoA reductase inhibitor
Alternative names
- Mevinolin
Biological description
Potent, competitive HMG CoA reductase inhibitor (Ki = 0.6 nM). Blood brain barrier permeable. Inhibits in vivo and in vitro cholesterol biosynthesis. Also reduces a-synuclein levels in vitro and in vivo.
Purity
> 98%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
(2S)-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl-2-methyl butanoate
Molecular Weight
404.54
Chemical structure
Molecular formula
C24H36O5
CAS Number
75330-75-5
Solubility
Soluble in DMSO to 100 mM and in ethanol to 50 mM
Storage instructions
Store at +4°C (desiccating conditions). Do not freeze.
Research areas
Biochemicals >> Research Area >> Stroke >> Signaling >> Lipid signaling >> HMG-CoA reductase >> Inhibitors
Biochemicals >> Research Area >> Respiratory disease >> Signaling >> Lipid signaling >> HMG-CoA reductase >> Inhibitors
Biochemicals >> Research Area >> Pain & inflammation >> Signaling >> Lipid signaling >> HMG-CoA reductase >> Inhibitors
Biochemicals >> Research Area >> Obesity >> Signaling >> Lipid signaling >> HMG-CoA reductase >> Inhibitors
Biochemicals >> Research Area >> Hypertension >> Signaling >> Lipid signaling >> HMG-CoA reductase >> Inhibitors
Biochemicals >> Research Area >> Heart disease >> Signaling >> Lipid signaling >> HMG-CoA reductase >> Inhibitors
Biochemicals >> Research Area >> Diabetes >> Signaling >> Lipid signaling >> HMG-CoA reductase >> Inhibitors
Biochemicals >> Research Area >> Cancer >> Signaling >> Lipid signaling >> HMG-CoA reductase >> Inhibitors
Biochemicals >> Research Area >> Alzheimer's Disease >> Signaling >> Lipid signaling >> HMG-CoA reductase >> Inhibitors
Biochemicals >> Pharmacology >> Signaling >> Lipid signaling >> HMG-CoA reductase >> Inhibitors
Biochemicals >> Pharmacology >> Enzymes >> HMG-CoA reductase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
References for Lovastatin (Mevinolin) (ab120614)
This product has been referenced in:
- Koob AO et al. Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies. Exp Neurol 221:267-74 (2010).Read more (PubMed: 19944097) »
- Chen GZ et al. Purification and characterization of 3-hydroxymethylglutaryl-coenzyme A reductase of Schistosoma mansoni: regulation of parasite enzyme activity differs from mammalian host. Exp Parasitol 73:82-92 (1991).Read more (PubMed: 1905241) »
See all 3 publications for this product
Publishing research using ab120614? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"