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Product Name
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Lrp2 / Megalin antibody
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See all Lrp2 / Megalin antibodies (2)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to Lrp2 / Megalin
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Immunogen
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Synthetic peptide corresponding to N-terminal residues of human LRP2
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Reacts with
(species key)
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Hu
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Tested applications
(see key)
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ELISA, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ELISA: Use at an assay dependent dilution.
WB: Use at a concentration of 1 µg/ml. Predicted molecular weight: 517 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Membrane; Single-pass type I membrane protein.
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Research areas
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Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Hormone biosynthesis
Developmental Biology >> Lineage specification >> Endoderm
Stem Cells >> Signaling Pathways >> Hedgehog >> Surface Molecules
Stem Cells >> Lineage Markers >> Endoderm
Cardiovascular >> Lipids / Lipoproteins >> Fatty Acids >> Binding proteins
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Relevance
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Lrp2 belongs to the LDLR family and contains 17 EGF-like domains, 36 LDL-receptor class A domains and 37 LDL-receptor class B repeats. Lrp2 specifically binds clusterin with high affinity, but also ligands in common with other family members: plasminogen, extracellular matrix components, plasminogen activator-plasminogen activator inhibitor type I complex, apolipoprotein E-enriched beta-VLDL, lipoprotein lipase, lactoferrin and calcium. It is invovled in receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B. Also it may participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release.
Lrp2 forms a multimeric complex together with a receptor-associated protein (RAP). It binds to ankyrin-repeat family A protein 2 (ANKRA2). It is present in absorptive epithelia, including renal proximal tubules.
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Lrp2 / Megalin antibody (ab56014) |
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Immunogen affinity purified
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Storage buffer
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Preservative: 0.01% Sodium Azide
Constituents: 50% Glycerol, PBS Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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0.500 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Lrp2 / Megalin antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to Lrp2 / Megalin
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Lrp2 / Megalin antibody - more information
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Customer reviews (feedback) regarding Lrp2 / Megalin antibody |
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