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Product Name 

Lrp2 / Megalin antibody

 

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Product type 

Primary antibodies

Description 

Rabbit polyclonal to Lrp2 / Megalin

Immunogen 

Synthetic peptide corresponding to N-terminal residues of human LRP2

Reacts with 
(species key)

Hu

Tested applications 
(see key)

ELISA, WB


Abreviews 

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(see key)


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Application notes 
(see key)

Recommended dilutions
ELISA: Use at an assay dependent dilution.
WB: Use at a concentration of 1 µg/ml. Predicted molecular weight: 517 kDa.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Membrane; Single-pass type I membrane protein.

Research areas 

Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Hormone biosynthesis
Developmental Biology >> Lineage specification >> Endoderm
Stem Cells >> Signaling Pathways >> Hedgehog >> Surface Molecules
Stem Cells >> Lineage Markers >> Endoderm
Cardiovascular >> Lipids / Lipoproteins >> Fatty Acids >> Binding proteins

Relevance 

Lrp2 belongs to the LDLR family and contains 17 EGF-like domains, 36 LDL-receptor class A domains and 37 LDL-receptor class B repeats. Lrp2 specifically binds clusterin with high affinity, but also ligands in common with other family members: plasminogen, extracellular matrix components, plasminogen activator-plasminogen activator inhibitor type I complex, apolipoprotein E-enriched beta-VLDL, lipoprotein lipase, lactoferrin and calcium. It is invovled in receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B. Also it may participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release.

Lrp2 forms a multimeric complex together with a receptor-associated protein (RAP). It binds to ankyrin-repeat family A protein 2 (ANKRA2). It is present in absorptive epithelia, including renal proximal tubules.

 

Lrp2 / Megalin antibody (ab56014)

Database links 

The links below go to external sites and will open in a new browser window

Entrez Gene

    

4036    (Human)

Omim

    

600073    (Human)

SwissProt

    

P98164    (Human)

Unigene

    

470538    (Human)

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

Preservative: 0.01% Sodium Azide
Constituents: 50% Glycerol, PBS

Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Sodium Azide MSDS

Form 

Liquid

Concentration 

0.500 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

 

At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Lrp2 / Megalin antibody is on this datasheet. But please do contact us if you would like any reassurance!


 

Search PubMed (MEDLINE) for references to Lrp2 / Megalin

 

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