Overview
- Product nameAnti-Lysosomal acid lipase antibodySee all Lysosomal acid lipase primary antibodies ...
- DescriptionMouse polyclonal to Lysosomal acid lipase
- Tested applicationsWB more details
- Species reactivityReacts with: Human
- Immunogen
Full length human Lysosomal acid lipase, amino acids 1-399 (AAH12287.1)
- Positive controlHuman pancreas tissue lysate, Lysosomal acid lipase transfected 293T cell lysate.
Properties
- FormLiquid
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: None
Constituents: 1X PBS, pH 7.2 -
Concentration information loading... - PurityProtein A purified
- Clonality Polyclonal
- IsotypeIgG
- Research Areas
Applications
Our Abpromise guarantee covers the use of ab89771 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Notes |
|---|---|
| WB | WB: Use a concentration of 1 µg/ml. Predicted molecular weight: 45 kDa. |
Target
- FunctionCrucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.
- Involvement in diseaseDefects in LIPA are the cause of Wolman disease (WOD) [MIM:278000]. WOD is a severe manifestation of LIPA deficiency, leading to the accumulation of cholesteryl esters and triglycerides in most tissues of the body. WOD occurs in infancy and is nearly always fatal before the age of 1 year.
Defects in LIPA are the cause of cholesteryl ester storage disease (CESD) [MIM:278000]. CESD is a mild manifestation of LIPA deficiency, leading to the accumulation of cholesteryl esters and triglycerides in most tissues of the body. It is characterized by late-onset. - Sequence similaritiesBelongs to the AB hydrolase superfamily. Lipase family.
- Cellular localizationLysosome.
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Database links
- Entrez Gene: 3988 Human
- Omim: 278000 Human
- SwissProt: P38571 Human
- Unigene: 643030 Human
Target information above from: UniProt accession
P38571
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010)
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Alternative names
- Acid Cholesteryl Ester Hydrolase antibodyCholesteryl Esterase antibodyLAL antibody
- LICH_HUMAN antibodyLIPA antibodyLipase A antibodyLysosomal acid lipase/cholesteryl ester hydrolase antibodySterol esterase antibody
see all
Anti-Lysosomal acid lipase antibody images
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Western blot - Lysosomal acid lipase antibody (ab89771)Anti-Lysosomal acid lipase antibody (ab89771) at 1 µg/ml + human pancreas tissue lysate at 50 µg
Predicted band size : 45 kDa
Observed band size : 45 kDa -
Western blot - Lysosomal acid lipase antibody (ab89771)All lanes : Anti-Lysosomal acid lipase antibody (ab89771) at 1 µg/ml
Lane 1 : Lysosomal acid lipase transfected 293T cell lysate
Lane 2 : Non-transfected lysate
Lysates/proteins at 25 µg per lane.
Predicted band size : 45 kDa
Observed band size : 45 kDa
References for Anti-Lysosomal acid lipase antibody (ab89771)
ab89771 has not yet been referenced specifically in any publications.
