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Anti-Lysozyme antibody - Lysosome Marker (ab391)

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Overview

Product name

Anti-Lysozyme antibody - Lysosome Marker
See all Lysozyme products (16) ...

Description

Rabbit polyclonal to Lysozyme - Lysosome Marker

Specificity

Assay by immunoelectrophoresis resulted in a single precipitin arc against purified and partially purified Lysozyme from hen egg white.

Tested applications

WB, IP, ELISAmore details

Cross reactivity

Reacts with

Chicken

Immunogen

Lysozyme from Hen Egg White

Positive control

Assayed against 1.0 ug of Lysozyme from hen egg white in a standard sandwich ELISA using Peroxidase conjugated Affinity Purified anti-Rabbit IgG [H&L] (Goat) and (ABTS (2,2’-azino-bis-[3-ethylbenthiazoline-6-sulfonic acid]) as a substrate for 30 minutes at room temperature.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.01% Sodium Azide
Constituents: 0.14M Sodium Chloride, 0.01M Sodium Phosphate. pH 7.4

Concentration

Concentration information loading...

Purity

IgG fraction

Purification notes

IgG fraction purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum as well as purified and partially purified Lysozyme.

Clonality

Polyclonal

Isotype

IgG

Research areas

Tags & Cell Markers >> Subcellular Markers >> Organelles >> Lysosome
Cardiovascular >> Blood >> Other
Immunology >> Adaptive Immunity >> T Cells >> Cytotoxic Cells
Immunology >> Innate Immunity >> Macrophage / Inflamm.

Applications

Show applications key

Our Abpromise guarantee covers the use of ab391 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

Involvement in disease

Defects in LYZ are a cause of amyloidosis type 8 (AMYL8) [MIM:105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.

Sequence similarities

Belongs to the glycosyl hydrolase 22 family.

Cellular localization

Secreted.

Target information above from: UniProt accessionP61626 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • 1 4 beta n acetylmuramidase c antibody
  • 1 antibody
  • 4-beta-N-acetylmuramidase C antibody
  • EC 3.2.1.17 antibody
  • LYSC_HUMAN antibody
  • Lysosyme antibody
  • Lysozyme (renal amyloidosis) antibody
  • Lysozyme C antibody
  • Lysozyme C precursor antibody
  • Lyz antibody
  • LZM antibody
  • Renal amyloidosis antibody
see all

Database links

References for Anti-Lysozyme antibody - Lysosome Marker (ab391)

This product has been referenced in:

  • Alvira CMet al. Nuclear factor-kappaB activation in neonatal mouse lung protects against lipopolysaccharide-induced inflammation. Am J Respir Crit Care Med 175:805-15 (2007).Read more (PubMed: 17255561) »
  • Sagiv Yet al. A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d. J Exp Med 204:921-8 (2007). WB.Read more (PubMed: 17403933) »

See all 2 publications for this product

Publishing research using ab391? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"