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Anti-MA2 antibody (ab83757)

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Overview

Product name

Anti-MA2 antibody
See all MA2 products (3) ...

Description

Rabbit polyclonal to MA2

Tested applications

WB, IHC-P, IHC-Frmore details

Cross reactivity

Reacts with

Human

Immunogen

A synthetic peptide from the C terminal region of human Paraneoplastic antigen Ma2, conjugated to an immunogenic carrier protein.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: Whole serum, 1X PBS

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Neuroscience >> Neurology process >> Neurodegenerative disease >> Other
Tags & Cell Markers >> Cell Type Markers >> Tumor Associated

Applications

Show applications key

Our Abpromise guarantee covers the use of ab83757 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide

    WB

     WB: 1/300 - 1/2000.Predi...Read more →

    WB: 1/300 - 1/2000.Predicted molecular weight: 42 kDa.(This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.)

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    IHC-P

     IHC-P: 1/300 - 1/2000.Pe...Read more →

    IHC-P: 1/300 - 1/2000.Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

  • IHC-Fr

     IHC-Fr: 1/300 - 1/2000.

    IHC-Fr: 1/300 - 1/2000.

Target

Relevance

In patients with cancer, symptoms of limbic and brain-stem dysfunction may result from a para-neoplastic disorder. Two proteins, Ma1 and Ma2, were discovered by presence of autoantibodies against them. Antibodies to Ma1 and Ma2 proteins identify a paraneoplastic disorder that affects the limbic system, brain stem, and cerebellum. These autoantibodies were used to clone Ma2, which codes for a protein (Ma2) that was recognized by serum from the 10 patients, but not by serum from 344 control subjects. Ma2 was selectively expressed by normal brain tissue and by the testicular tumors of the patients. Ma2 shares homology with Ma1, a "brain-testis-cancer" gene related to other para-neoplastic syndromes and tumors.

Cellular localization

Nucleus; nucleolus

Alternative names

  • 40 kDa neuronal protein antibody
  • KIAA0883 antibody
  • MM2 antibody
  • Paraneoplastic neuronal antigen antibody
  • Paraneoplastic neuronal antigen MM2 antibody
  • PNMA2 antibody
  • Retrotransposon gag domain containing 2 antibody
  • RGAG2 antibody
see all

Database links

References for Anti-MA2 antibody (ab83757)

ab83757 has not yet been referenced specifically in any publications.

Publishing research using ab83757? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"