MADD peptide (ab8384)

Product Name 

MADD peptide

Product type 

Proteins and Peptides

Tested applications 
(see key)

BL

Application notes 
(see key)

Recommended dilutions
The peptide is used for blocking the activity of ab2043. Incubatingthe peptide with equal volume of antibody for 30 min at 37°C usually completely blocks theantibody activity in Western blotting.

Research areas 

Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Integration of energy metabolism
Signal Transduction >> Metabolism >> Mitochondrial

Relevance 

ETFA (MADD) participates in catalyzing the initial step of the mitochondrial fatty acid beta oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric,2-methyl-butyric, and isovaleric acids. Two transcript variants encoding different isoforms have been found for this gene.

Storage buffer 

PBS with 0.1% BSA 0.02% sodium azide pH7.2

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

0.200 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Sequence 

AAVHSSEEDLRTPPRPVSS
Amino acids 1570 to 1588 of human MADD (1)

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