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Products:Cancer >> Tumor immunology >> Tumor-associated antigens
Overview
Product name
Anti-MAGEA10 antibody - Carboxyterminal end
See all MAGEA10 products (2) ...
Description
Rabbit polyclonal to MAGEA10 - Carboxyterminal end
Tested applications
WB, ELISA, IHC-Pmore details
Cross reactivity
Reacts with
Human
Immunogen
A KLH conjugated synthetic peptide selected from the C-terminal region of human MAGEA10.
Positive control
human breast carcinoma tissue and HL60 lysate.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Protein G purified
Purification notes
This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Tumor biomarkers >> Tumor antigens
Cancer >> Tumor immunology >> Tumor-associated antigens
Applications
Show applications key
Our Abpromise guarantee covers the use of ab71788 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notes
ELISA: 1/1000.
IHC-P: 1/50 - 1/100.
WB: 1/100 - 1/500. Detects a band of approximately 41 kDa (predicted molecular weight: 41 kDa). A range of other bands are detected from ~60-140 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. MAGEA10 contains one MAGE domain. Its function is not known, though it may play a role in embryonal development and tumor transformation or aspects of tumor progression. MAGEA10 is expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta.
Alternative names
- Cancer/testis antigen 1.10 antibody
- CT1.10 antibody
- MAGE 10 antigen antibody
see all
Database links
- Entrez Gene: 4109 Human
- Omim: 300343 Human
- SwissProt: P43363 Human
Anti-MAGEA10 antibody - Carboxyterminal end images:
Western blot - MAGEA10 antibody - Carboxyterminal end (ab71788)
Anti-MAGEA10 antibody - Carboxyterminal end (ab71788) at 1/100 dilution + HL60 lysate at 12.5 µg
Predicted band size : 41 kDa
Observed band size : 41 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - MAGEA10 antibody - Carboxyterminal end (ab71788)
Formalin-fixed, paraffin-embedded human breast carcinoma tissue reacted with ab71788 at a 1:50 dilution, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
References for Anti-MAGEA10 antibody - Carboxyterminal end (ab71788)
ab71788 has not yet been referenced specifically in any publications.
Publishing research using ab71788? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"