You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Related products

Reassurance, Refunds & Replacements

If your product does not perform as described on this datasheet, we will refund or replace your product...

Read our guarantee »
 

Anti-MAGED1 antibody (ab58584)

CodeSizePriceAbpointsAvailability
    
Add to basket
 
  • -
  •   
  •   
  •   
  •  
  •   
  •   
Updating...

Overview

Product name

Anti-MAGED1 antibody
See all MAGED1 products (4) ...

Description

Rabbit polyclonal to MAGED1

Specificity

This antibody recognizes the ~85 kDa MAGED1 protein in PC12nrr5 cells.

Tested applications

WB, IP, ICCmore details

Cross reactivity

Reacts with

Mouse, Rat, Human

Immunogen

A tagged fusion protein, corresponding to amino acids 53-295 of MAGED1

Positive control

Positive Control: PC12nrr5 cells Negative Control: Normal rabbit IgG

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: Whole serum

Purity

Whole antiserum

Purification notes

Rabbit polyclonal antibody supplied as undiluted serum.

Clonality

Polyclonal

Isotype

IgG

Research areas

Cell Biology >> Apoptosis >> Intracellular >> p53 Pathway
Cell Biology >> Apoptosis >> Intracellular >> Associated Proteins

Applications

Show applications key

Our Abpromise guarantee covers the use of ab58584 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide

    WB

     WB: 1/2000Detects a band...Read more →

    WB: 1/2000Detects a band of approximately 85 kDa (predicted molecular weight: 86 kDa).

  • IP

     IP: 1/1000

    IP: 1/1000

  • ICC

     ICC: 1/1000

    ICC: 1/1000

Target

Function

Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Binds p75NTR and antagonizes its association with TrkA, inhibits cell cycle progression, and facilitates p75NTR-mediated apoptosis. May act as a regulator of the function of DLX family members. May regulate p53 transcriptional activity and inhibit cell proliferation. Enhances p53 phosphorylation and accumulation.

Tissue specificity

Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.

Sequence similarities

Contains 1 MAGE domain.

Cellular localization

Cytoplasm. Cell membrane. Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.

Target information above from: UniProt accessionQ9Y5V3 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • DLXIN 1 antibody
  • MAGD1_HUMAN antibody
  • MAGE D1 antigen antibody
  • MAGE tumor antigen CCF antibody
  • MAGE-D1 antigen antibody
  • Maged1 antibody
  • Melanoma antigen family D 1 antibody
  • Melanoma associated antigen D1 antibody
  • Melanoma-associated antigen D1 antibody
  • Neurotrophin receptor interacting MAGE homolog antibody
  • Neurotrophin receptor-interacting MAGE homolog antibody
  • NRAGE antibody
  • PP2250 antibody
see all

Database links

see all

References for Anti-MAGED1 antibody (ab58584)

ab58584 has not yet been referenced specifically in any publications.

Publishing research using ab58584? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"