MAL antibody (ab15418)

Product Name 

MAL antibody

Product type 

Primary antibodies

Description 

Rabbit polyclonal to MAL

Immunogen 

Synthetic peptide: CFDGFTY(R/K)HYHENI, corresponding to amino acids 114-126 of rat and human MAL.
BLAST 'CFDGFTY(R/K)HYHENI' with or

Reacts with 
(species key)

Rat

Tested applications 
(see key)

WB

Abreviews 

Customer reviews (see key)

Read about Abreviews (Read all Abreviews)

Application notes 
(see key)

Recommended dilutions
WB: 1/500. Detects a band of approximately 17 kDa (predicted molecular weight: 18 kDa).

Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

Rat kidney extracts.

Cellular localization 

Integral membrane protein.

Research areas 

Neuroscience >> Neurology process >> Neurogenesis
Cell Biology >> Cell Cycle >> Cell differentiation
Cell Biology >> Apoptosis >> Intracellular >> Associated Proteins

Relevance 

MAL, a nonglycosylated integral membrane proteolipid, has been identified as a major internal component of glycolipid enriched membrane (GEM) microdomains. MAL is the first integral membrane proteolipid component to have been shown as a necessary element in the cellular apical sorting apparatus for newly synthesized proteins. In its steady state this highly hydrophobic proteolipid, resides predominantly in the apical zone of polarized epithelial cells. It has also been shown in itinerant protein cycling between the plasma membrane and endosomes and in other cells. This 17 kDa proteolipid contains four putative transmembrane domains. These domains along with its protein trafficking properties are defined by the specific signals delegated by its specific amino acid sequence.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

Preservative: 0.05% Sodium Azide
Constituents: PBS, 1mg/ml BSA.

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

References for MAL antibody (ab15418)

  This product has been used in:

Kamsteeg EJ et al. MAL decreases the internalization of the aquaporin-2 water channel. Proc Natl Acad Sci U S A 104:16696-701 (2007). PubMed: 17940053

If you publish research using ab15418 please let us know so that we can cite the reference on this datasheet.

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