Anti-MAL2 antibody (ab75347)
Key features and details
- Rabbit polyclonal to MAL2
- Suitable for: ELISA, ICC, WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-MAL2 antibody
See all MAL2 primary antibodies -
Description
Rabbit polyclonal to MAL2 -
Host species
Rabbit -
Tested applications
Suitable for: ELISA, ICC, WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptide derived from the N-terminal domain of human MAL2
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Constituent: Whole serum -
Concentration information loading...
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Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab75347 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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ELISA |
Use at an assay dependent concentration.
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ICC |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration.
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Notes |
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ELISA
Use at an assay dependent concentration. |
ICC
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
Target
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Function
Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway. -
Tissue specificity
Predominantly expressed in kidney, lung, and liver. Also found in thyroid gland, stomach and, at lower levels in testis and small intestine. -
Sequence similarities
Belongs to the MAL family.
Contains 1 MARVEL domain. -
Cellular localization
Cell membrane. Apical cell membrane. Endomembrane system. Cytoplasm > perinuclear region. Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface. In hepatocytes, as well as in polarized hepatoma HepG2 cells, found in the canalicular membrane, equivalent to the apical surface, beneath the canalicular actin cytoskeleton. In non-polarized HepG2 cells, distributed to the perinuclear region. - Information by UniProt
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Database links
- Entrez Gene: 114569 Human
- Entrez Gene: 105853 Mouse
- Entrez Gene: 362911 Rat
- Omim: 609684 Human
- SwissProt: Q969L2 Human
- SwissProt: Q8BI08 Mouse
- Unigene: 201083 Human
- Unigene: 410994 Mouse
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Alternative names
- MAL 2 antibody
- MAL proteolipid protein 2 antibody
- Mal, T cell differentiation protein 2 antibody
see all
Protocols
Datasheets and documents
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Datasheet download
References (8)
ab75347 has been referenced in 8 publications.
- Rodriguez E et al. Analysis of the glyco-code in pancreatic ductal adenocarcinoma identifies glycan-mediated immune regulatory circuits. Commun Biol 5:41 (2022). PubMed: 35017635
- Yuan J et al. Multi-Omics Analysis of the Therapeutic Value of MAL2 Based on Data Mining in Human Cancers. Front Cell Dev Biol 9:736649 (2021). PubMed: 35111745
- Tao L et al. FTO modifies the m6A level of MALAT and promotes bladder cancer progression. Clin Transl Med 11:e310 (2021). PubMed: 33634966
- Zhang B et al. MAL2 interacts with IQGAP1 to promote pancreatic cancer progression by increasing ERK1/2 phosphorylation. Biochem Biophys Res Commun 554:63-70 (2021). PubMed: 33780861
- López-Coral A et al. MAL2-Induced Actin-Based Protrusion Formation is Anti-Oncogenic in Hepatocellular Carcinoma. Cancers (Basel) 12:N/A (2020). PubMed: 32059473
- Lamm KYB et al. Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome. Elife 7:N/A (2018). PubMed: 29309034
- Li J et al. The four-transmembrane protein MAL2 and tumor protein D52 (TPD52) are highly expressed in colorectal cancer and correlated with poor prognosis. PLoS One 12:e0178515 (2017). IHC-P ; Human . PubMed: 28562687
- Katz E et al. An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer. PLoS One 6:e17083 (2011). WB . PubMed: 21347235