Recombinant Anti-MALT1/MLT antibody [EPR604] (ab109724)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR604] to MALT1/MLT
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
Overview
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Product name
Anti-MALT1/MLT antibody [EPR604]
See all MALT1/MLT primary antibodies -
Description
Rabbit monoclonal [EPR604] to MALT1/MLT -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details
Unsuitable for: Flow Cyt,IHC-P or IP -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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Positive control
- Jurkat,K562,bone marrow, and PBMC lysates
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General notes
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Monoclonal -
Clone number
EPR604 -
Isotype
IgG -
Research areas
Associated products
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Alternative Versions
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab109724 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/1000 - 1/10000. Predicted molecular weight: 92 kDa.
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Notes |
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WB
1/1000 - 1/10000. Predicted molecular weight: 92 kDa. |
Target
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Function
Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. -
Tissue specificity
Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. -
Involvement in disease
Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma. -
Sequence similarities
Belongs to the peptidase C14B family.
Contains 1 death domain.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains. -
Cellular localization
Cytoplasm > perinuclear region. Nucleus. Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10. - Information by UniProt
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Database links
- Entrez Gene: 10892 Human
- Omim: 604860 Human
- SwissProt: Q9UDY8 Human
- Unigene: 601217 Human
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Alternative names
- Caspase like protein antibody
- DKFZp434L132 antibody
- IMD12 antibody
see all
Images
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All lanes : Anti-MALT1/MLT antibody [EPR604] (ab109724) at 1/1000 dilution
Lane 1 : Jurkat lysate
Lane 2 : K562 lysate
Lane 3 : Bone marrow lysate
Lane 4 : PBMC lysates
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : Standard HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size: 92 kDa
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab109724 has not yet been referenced specifically in any publications.