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Anti-MAP1 antibody (ab25954)

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Overview

Product name

Anti-MAP1 antibody
See all MAP1 products (5) ...

Description

Rabbit polyclonal to MAP1

Specificity

ab25954 recognises MAP-1.

Tested applications

WBmore details

Cross reactivity

Reacts with

Mouse, Human

Immunogen

A 15 amino acid synthetic peptide from near the center of MAP-1(Human)

Positive control

EL4 cell lysate.

Properties

Form

Liquid

Storage instructions

Store at +4°C.

Storage buffer

Preservative: 0.02% Sodium Azide
Constituents: PBS

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

Research areas

Cell Biology >> Apoptosis >> Intracellular >> Bcl2 Family

  • Western blot - MAP1 antibody (ab25954)Western blot - MAP1 antibody (ab25954) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab25954 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.

Tissue specificity

Ubiquitously expressed with higher levels in heart and brain.

Sequence similarities

Belongs to the PNMA family.

Domain

The BH3-like domain is required for association with BAX and for mediating apoptosis. The three BH domains (BH1, BH2, and BH3) of BAX are all required for mediating protein-protein interaction.

Target information above from: UniProt accessionQ96BY2 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • MAP 1 antibody
  • MAP-1 antibody
  • MAP1 antibody
  • MOAP1 antibody
  • MOAP1_HUMAN antibody
  • Modulator of apoptosis 1 antibody
  • Modulator of Apoptosis antibody
  • Modulator of Apoptosis antibody
  • Paraneoplastic antigen like 4 antibody
  • Paraneoplastic antigen MA4 antibody
  • PNMA4 antibody
see all

Database links

Anti-MAP1 antibody images:

  Western blot - MAP1 antibody (ab25954)

Western blot - MAP1 antibody (ab25954)

Lane 1 : Anti-MAP1 antibody (ab25954) at 1 µg/ml
Lane 2 : Anti-MAP1 antibody (ab25954) at 2 µg/ml
Lane 3 : Anti-MAP1 antibody (ab25954) at 4 µg/ml

Lane 1 : EL4 cell lysate.
Lane 2 : EL4 cell lysate.
Lane 3 : EL4 cell lysate.


Predicted band size : 40 kDa
Observed band size : ~35 kDa (why is the actual band size different from the predicted?)

References for Anti-MAP1 antibody (ab25954)

This product has been referenced in:

  • Wills J  et al. Tauopathic Changes in the Striatum of A53T a-Synuclein Mutant Mouse Model of Parkinson's Disease. PLoS One 6:e17953 (2011).Read more (PubMed: 21445308) »

See 1 publication for this product

Publishing research using ab25954? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"