Overview

  • Product name
  • Description
    Rabbit polyclonal to MAP1
  • Specificity
    ab25954 recognises MAP-1.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    A 15 amino acid synthetic peptide from near the center of MAP-1(Human)

  • Positive control
    • EL4 cell lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab25954 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 40 kDa.

Target

  • Function
    Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.
  • Tissue specificity
    Ubiquitously expressed with higher levels in heart and brain.
  • Sequence similarities
    Belongs to the PNMA family.
  • Domain
    The BH3-like domain is required for association with BAX and for mediating apoptosis. The three BH domains (BH1, BH2, and BH3) of BAX are all required for mediating protein-protein interaction.
  • Information by UniProt
  • Database links
  • Alternative names
    • MAP 1 antibody
    • MAP-1 antibody
    • MAP1 antibody
    • MOAP1 antibody
    • MOAP1_HUMAN antibody
    • Modulator of apoptosis 1 antibody
    • Modulator of Apoptosis antibody
    • Paraneoplastic antigen like 4 antibody
    • Paraneoplastic antigen Ma4 antibody
    • paraneoplastic Ma antigen family member 4 antibody
    • PNMA4 antibody
    see all

Images

  • Lane 1 : Anti-MAP1 antibody (ab25954) at 1 µg/ml
    Lane 2 : Anti-MAP1 antibody (ab25954) at 2 µg/ml
    Lane 3 : Anti-MAP1 antibody (ab25954) at 4 µg/ml

    Lane 1 : EL4 cell lysate.
    Lane 2 : EL4 cell lysate.
    Lane 3 : EL4 cell lysate.


    Predicted band size : 40 kDa
    Observed band size : ~35 kDa (why is the actual band size different from the predicted?)

References

This product has been referenced in:
  • Wills J  et al. Tauopathic Changes in the Striatum of A53T a-Synuclein Mutant Mouse Model of Parkinson's Disease. PLoS One 6:e17953 (2011). Read more (PubMed: 21445308) »
  • Haggerty T  et al. Hyperphosphorylated Tau in an a-synuclein-overexpressing transgenic model of Parkinson's disease. Eur J Neurosci 33:1598-610 (2011). Read more (PubMed: 21453448) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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